Development and characterization of alginate and chitosan hybrid films for dual administration of neomycin and lidocaine

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dc.contributor.authorChagas V.L.
dc.contributor.authorSilva L.D.S.
dc.contributor.authorSousa C.E.M.D.
dc.contributor.authorSilva R.G.
dc.contributor.authorCarvalho L.R.D.S.
dc.contributor.authorSilva I.S.S.
dc.contributor.authorBazan J.M.N.
dc.contributor.authorTofanello A.
dc.contributor.authorGarcia W.
dc.contributor.authorTeixeira C.S.
dc.contributor.authorCarvalho E.M.
dc.contributor.authorMartins S.M.D.S.B.
dc.contributor.authorCorreia M.T.D.S.
dc.contributor.authorNascimento da Silva L.C.
dc.date.accessioned2025-05-01T06:24:37Z
dc.date.available2025-05-01T06:24:37Z
dc.date.issued2025
dc.description.abstract© 2025Wound care is frequently hindered by infections, which prevent recovery and adversely affect patients' quality of life. A prevalent example is the presence of bacteria such as Staphylococcus aureus, which can lead to severe inflammation. This study developed and characterized hybrid films composed of alginate and chitosan, incorporating the antimicrobial agent neomycin and the local anesthetic lidocaine, to be applied as a dressing for wound treatment. The research employed an experimental design to identify the optimal formulation, evaluating aspects such as uniformity, cracking, and consistency of the films. After determining the ideal formulation, the films were evaluated: roughness, moisture absorption, swelling, and thickness. Additionally, advanced analytical techniques such as electron microscopy and spectroscopy were employed to provide a comprehensive characterization of the films. The results indicated that the films maintained good chemical stability after incorporating the drugs, effectively absorbed liquids, and exhibited suitable thickness. Biocompatibility was confirmed through hemolysis and antimicrobial activity tests. The films containing both neomycin and lidocaine exhibited good efficacy against S. aureus, highlighting the enhanced bacterial inhibition when both drugs were present. These hybrid films show promise as dressings, possessing antimicrobial, anesthetic, and biocompatible properties, along with the ability to absorb liquids.
dc.description.volume309
dc.identifier.doi10.1016/j.ijbiomac.2025.142632
dc.identifier.issnNone
dc.identifier.urihttps://dspace.mackenzie.br/handle/10899/40616
dc.relation.ispartofInternational Journal of Biological Macromolecules
dc.rightsAcesso Restrito
dc.subject.otherlanguageAlginate
dc.subject.otherlanguageChitosan
dc.subject.otherlanguageFilms
dc.subject.otherlanguageNeomycin
dc.subject.otherlanguageWounds
dc.titleDevelopment and characterization of alginate and chitosan hybrid films for dual administration of neomycin and lidocaine
dc.typeArtigo
local.scopus.citations0
local.scopus.eid2-s2.0-105001860251
local.scopus.subjectCharacterization of the films
local.scopus.subjectHaemolysis
local.scopus.subjectHybrid film
local.scopus.subjectLocal anaesthetic
local.scopus.subjectMoisture absorption
local.scopus.subjectNeomycin
local.scopus.subjectOptimal formulation
local.scopus.subjectQuality of life
local.scopus.subjectStaphylococcus aureus
local.scopus.subjectWound
local.scopus.updated2025-05-01
local.scopus.urlhttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=105001860251&origin=inward
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