Development and characterization of alginate and chitosan hybrid films for dual administration of neomycin and lidocaine

Chagas V.L.; Silva L.D.S.; Sousa C.E.M.D.; Silva R.G.; Carvalho L.R.D.S.; Silva I.S.S.; Bazan J.M.N.; Tofanello A.; Garcia W.; Teixeira C.S.; Carvalho E.M.; Martins S.M.D.S.B.; Correia M.T.D.S.; Nascimento da Silva L.C.

Development and characterization of alginate and chitosan hybrid films for dual administration of neomycin and lidocaine

Tipo

Artigo

Data de publicação

2025

Periódico

International Journal of Biological Macromolecules

Citações (Scopus)

0

Autores

Chagas V.L.
Silva L.D.S.
Sousa C.E.M.D.
Silva R.G.
Carvalho L.R.D.S.
Silva I.S.S.
Bazan J.M.N.
Tofanello A.
Garcia W.
Teixeira C.S.
Carvalho E.M.
Martins S.M.D.S.B.
Correia M.T.D.S.
Nascimento da Silva L.C.

Resumo

© 2025Wound care is frequently hindered by infections, which prevent recovery and adversely affect patients' quality of life. A prevalent example is the presence of bacteria such as Staphylococcus aureus, which can lead to severe inflammation. This study developed and characterized hybrid films composed of alginate and chitosan, incorporating the antimicrobial agent neomycin and the local anesthetic lidocaine, to be applied as a dressing for wound treatment. The research employed an experimental design to identify the optimal formulation, evaluating aspects such as uniformity, cracking, and consistency of the films. After determining the ideal formulation, the films were evaluated: roughness, moisture absorption, swelling, and thickness. Additionally, advanced analytical techniques such as electron microscopy and spectroscopy were employed to provide a comprehensive characterization of the films. The results indicated that the films maintained good chemical stability after incorporating the drugs, effectively absorbed liquids, and exhibited suitable thickness. Biocompatibility was confirmed through hemolysis and antimicrobial activity tests. The films containing both neomycin and lidocaine exhibited good efficacy against S. aureus, highlighting the enhanced bacterial inhibition when both drugs were present. These hybrid films show promise as dressings, possessing antimicrobial, anesthetic, and biocompatible properties, along with the ability to absorb liquids.

Assuntos Scopus

Characterization of the films , Haemolysis , Hybrid film , Local anaesthetic , Moisture absorption , Neomycin , Optimal formulation , Quality of life , Staphylococcus aureus , Wound