Is the FVB/N mouse strain truly resistant to diet-induced obesity?

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dc.contributor.authorNascimento-Sales M.
dc.contributor.authorFredo-da-Costa I.
dc.contributor.authorBorges Mendes A.C.B.
dc.contributor.authorMelo S.
dc.contributor.authorRavache T.T.
dc.contributor.authorGomez T.G.B.
dc.contributor.authorGaisler-Silva F.
dc.contributor.authorRibeiro M.O.
dc.contributor.authorSantos A.R.
dc.contributor.authorCarneiro-Ramos M.S.
dc.contributor.authorChristoffolete M.A.
dc.date.accessioned2024-03-13T00:49:32Z
dc.date.available2024-03-13T00:49:32Z
dc.date.issued2017
dc.description.abstract© 2017 The Authors. Physiological Reports published by Wiley Periodicals, Inc. on behalf of The Physiological Society and the American Physiological Society.C57Bl/6J mice are the gold standard animal model of diet-induced obesity. These animals become obese with higher adiposity, blood fasting glucose, triglycerides, and total cholesterol when fed a high-fat diet (HFD). Conversely, the FVB/N mouse line is thought to be resistant to diet-induced obesity, with low or no weight gain and adiposity in response to a HFD. In this study, we investigated whether FVB/N mice are resistant or susceptible to metabolic disorder that is promoted by a HFD. Biometric parameters and blood chemistry were analyzed in C57Bl/6J and FVB/N mice that were fed a chow diet or HFD. Glucose and insulin sensitivity were assessed by performing the glucose tolerance test and measuring serum insulin/glucose and homeostasis model assessment-insulin resistance. Metabolism-related gene expression was investigated by real-time reverse transcription polymerase chain reaction. Adipocyte morphology and liver steatosis were evaluated using standard histology. FVB/N mice had higher adiposity than C57Bl/6J mice that were fed a chow diet and were glucose intolerant. FVB/N mice that were fed a HFD presented higher insulin resistance and greater liver steatosis. Epididymal white adipose tissue exhibited severe inflammation in FVB/N mice that were fed a HFD. The FVB/N mouse strain is suitable for studies of diet-induced obesity, and the apparent lack of a HFD-induced response may reveal several strain-specific events that are triggered by a HFD. Further studies of the FVB/N background may shed light on the complex multifactorial symptoms of obesity and metabolic syndrome.
dc.description.issuenumber9
dc.description.volume5
dc.identifier.doi10.14814/phy2.13271
dc.identifier.urihttps://dspace.mackenzie.br/handle/10899/35767
dc.relation.ispartofPhysiological Reports
dc.rightsAcesso Aberto
dc.subject.otherlanguageC57Bl/6J
dc.subject.otherlanguagediet-induced obesity
dc.subject.otherlanguageFVB/N
dc.subject.otherlanguagegenetic background
dc.subject.otherlanguageglucose tolerance
dc.titleIs the FVB/N mouse strain truly resistant to diet-induced obesity?
dc.typeArtigo
local.scopus.citations21
local.scopus.eid2-s2.0-85019247467
local.scopus.subjectAdiposity
local.scopus.subjectAnimals
local.scopus.subjectBlood Glucose
local.scopus.subjectDiet, High-Fat
local.scopus.subjectDisease Models, Animal
local.scopus.subjectGenetic Background
local.scopus.subjectMale
local.scopus.subjectMice
local.scopus.subjectMice, Inbred C57BL
local.scopus.subjectMice, Obese
local.scopus.subjectObesity
local.scopus.updated2024-05-01
local.scopus.urlhttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85019247467&origin=inward
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