Oncogenic osteomalacia: Localization of underlying peripheral tumor with 99mTc-sestamibi scintigraphy Osteomalácia oncogênica: Cintilografia com sestamibi- 99mTc na localização do tumor periférico

Biagini G.L.K.; Coutinho P.R.; Jonasson T.H.; Ueda C.E.; Gama R.R.

Oncogenic osteomalacia: Localization of underlying peripheral tumor with 99mTc-sestamibi scintigraphy Osteomalácia oncogênica: Cintilografia com sestamibi- 99mTc na localização do tumor periférico

Tipo

Artigo

Data de publicação

2008

Periódico

Arquivos Brasileiros de Endocrinologia e Metabologia

Citações (Scopus)

6

Autores

Biagini G.L.K.
Coutinho P.R.
Jonasson T.H.
Ueda C.E.
Gama R.R.

Resumo

Oncogenic osteomalacia is a paraneoplastic syndrome usually induced by bone or soft tissue tumors. It is presented by the development of pain and fractures with hypophosphatemia, hyperphosphaturia, and inappropriate normal/low plasma 1,25(OH) 2D 3 concentration. After the removal of the tumor the complete resolution of all biochemical and clinical abnormalities is the main characteristic. A case of a 44-year-old female with difficulty in walking due to leg pain and generalized muscle weakness and hypophosphatemia, with relative hyperphosphaturia, is described. A whole-body 99mTc- sestamibi scintigraphy showed accumulation in the left thigh region, and a small tumor was detected by ultrasound examination. By removal of the tumor, a lipoma, the symptoms improved significantly after a month, with complete recovery by the fourth month. In this case, 99mTc-sestamibi scintigraphy was useful in identifying the location of the tumor, which caused oncogenic osteomalacia. Copyright© ABE&M.