The neurobiological bases of obsessive-compulsive disorder and Tourette syndrome As bases neurobiológicas do transtorno obsessivo-compulsivo e da síndrome de Tourette.
Tipo
Artigo de revisão
Data de publicação
2004
Periódico
Jornal de pediatria
Citações (Scopus)
12
Autores
Mercadante M.T.
Rosario-Campos M.C.
Quarantini L.C.
Sato F.P.
Rosario-Campos M.C.
Quarantini L.C.
Sato F.P.
Orientador
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Membros da banca
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Resumo
OBJECTIVE: To describe and discuss evidence-based articles on the neurobiology of obsessive-compulsive disorder and Tourette syndrome. SOURCES OF DATA: A review of the most relevant papers on the phenomenology, neuroanatomy, neuroimaging, genetic and immunological aspects of these two disorders was performed. SUMMARY OF THE FINDINGS: Ritualistic behaviors and repetitive thoughts have been extensively studied in the last years. The definitions of obsessive-compulsive disorder and Tourette syndrome emphasize the existence of a continuum of symptoms, with high prevalence in the general population. Neurobiological findings have implicated genetic and immunological factors in the etiology of these two disorders. CONCLUSIONS: Advances in neuroscience triggered genetic and immunological research studies, allowing new perspectives on the treatment of obsessive-compulsive disorder and Tourette syndrome patients.