Activity of antimicrobial combinations against KPC-2-producing Klebsiella pneumoniae in a rat model and time-kill assay

Página do item simplificado
dc.contributor.authorToledo P.V.M.
dc.contributor.authorAranha A.A.
dc.contributor.authorArend L.N.
dc.contributor.authorRibeiro V.
dc.contributor.authorZavascki A.P.
dc.contributor.authorTuon F.F.
dc.date.accessioned2024-03-13T00:56:58Z
dc.date.available2024-03-13T00:56:58Z
dc.date.issued2015
dc.description.abstractCopyright © 2015, American Society for Microbiology. All Rights Reserved.This study evaluated the efficacy of tigecycline (TIG), polymyxin B (PMB), and meropenem (MER) in 80 rats challenged with Klebsiella pneumoniae carbapenemase (KPC)-producing K. pneumoniae infection. A time-kill assay was performed with the same strain. Triple therapy and PMB+TIG were synergistic, promoted 100% survival, and produced negative peritoneal cultures, while MER+TIG showed lower survival and higher culture positivity than other regimens (P = 0.018) and was antagonistic. In vivo and in vitro studies showed that combined regimens, except MER+TIG, were more effective than monotherapies for this KPC-producing strain.
dc.description.firstpage4301
dc.description.issuenumber7
dc.description.lastpage4304
dc.description.volume59
dc.identifier.doi10.1128/AAC.00323-15
dc.identifier.issn1098-6596
dc.identifier.urihttps://dspace.mackenzie.br/handle/10899/36185
dc.relation.ispartofAntimicrobial Agents and Chemotherapy
dc.rightsAcesso Aberto
dc.titleActivity of antimicrobial combinations against KPC-2-producing Klebsiella pneumoniae in a rat model and time-kill assay
dc.typeArtigo
local.scopus.citations27
local.scopus.eid2-s2.0-84931282008
local.scopus.subjectAnimals
local.scopus.subjectAnti-Bacterial Agents
local.scopus.subjectAscitic Fluid
local.scopus.subjectbeta-Lactamases
local.scopus.subjectColony Count, Microbial
local.scopus.subjectDrug Combinations
local.scopus.subjectDrug Interactions
local.scopus.subjectDrug Synergism
local.scopus.subjectFemale
local.scopus.subjectKaplan-Meier Estimate
local.scopus.subjectKlebsiella Infections
local.scopus.subjectKlebsiella pneumoniae
local.scopus.subjectMale
local.scopus.subjectMicrobial Sensitivity Tests
local.scopus.subjectRats
local.scopus.subjectRats, Wistar
local.scopus.updated2024-05-01
local.scopus.urlhttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84931282008&origin=inward
Arquivos
Coleções
Artigos de periódico