Activity of antimicrobial combinations against KPC-2-producing Klebsiella pneumoniae in a rat model and time-kill assay
Tipo
Artigo
Data de publicação
2015
Periódico
Antimicrobial Agents and Chemotherapy
Citações (Scopus)
27
Autores
Toledo P.V.M.
Aranha A.A.
Arend L.N.
Ribeiro V.
Zavascki A.P.
Tuon F.F.
Aranha A.A.
Arend L.N.
Ribeiro V.
Zavascki A.P.
Tuon F.F.
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Resumo
Copyright © 2015, American Society for Microbiology. All Rights Reserved.This study evaluated the efficacy of tigecycline (TIG), polymyxin B (PMB), and meropenem (MER) in 80 rats challenged with Klebsiella pneumoniae carbapenemase (KPC)-producing K. pneumoniae infection. A time-kill assay was performed with the same strain. Triple therapy and PMB+TIG were synergistic, promoted 100% survival, and produced negative peritoneal cultures, while MER+TIG showed lower survival and higher culture positivity than other regimens (P = 0.018) and was antagonistic. In vivo and in vitro studies showed that combined regimens, except MER+TIG, were more effective than monotherapies for this KPC-producing strain.
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Assuntos Scopus
Animals , Anti-Bacterial Agents , Ascitic Fluid , beta-Lactamases , Colony Count, Microbial , Drug Combinations , Drug Interactions , Drug Synergism , Female , Kaplan-Meier Estimate , Klebsiella Infections , Klebsiella pneumoniae , Male , Microbial Sensitivity Tests , Rats , Rats, Wistar