Response of leucine metabolism to hyperinsulinemia in hypothyroid patients before and after thyroxine replacement

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dc.contributor.authorRochon C.
dc.contributor.authorTauveron I.
dc.contributor.authorDejax C.
dc.contributor.authorBenoit P.
dc.contributor.authorCapitan P.
dc.contributor.authorBayle G.
dc.contributor.authorPrugnaud J.
dc.contributor.authorFabricio A.
dc.contributor.authorBerry C.
dc.contributor.authorChampredon C.
dc.contributor.authorThieblot P.
dc.contributor.authorGrizard J.
dc.date.accessioned2024-03-13T01:47:11Z
dc.date.available2024-03-13T01:47:11Z
dc.date.issued2000
dc.description.abstractWe have investigated the effect of hypothyroidism and insulin on protein metabolism in humans. Six hypothyroid patients were studied in a postabsorptive state before and after 5 months of regular treatment for hypothyroidism (153 ± 17 μg/day of L-T4). The effect of insulin was assessed under hyperinsulinemic euglycemic and eukalemic conditions. Insulin was infused for 140 min at 0.0063 ± 0.0002 nmol/kg·min. An amino acid infusion was used to blunt insulin-induced hypoaminoacidemia. Whole body protein turnover was measured using L-[1-3C] leucine. When compared to L-T4-induced subclinical thyrotoxic state, hypothyroidism induced a significant decrease (P < 0.05) in leucine endogenous appearance rate (a reflection of proteolysis; 0.89 ± 0.09 vs. 1.33 ± 0.05 μmol/kg·min), oxidation (0.19 ± 0.02 vs. 0.25 ± 0.03 μmol/kg·min), and nonoxidative disposal (a reflection of protein synthesis; 0.87 ± 0.11 vs. 1.30 ± 0.05 μmol/kg·min). Insulin lowered proteolysis during both the subclinical thyrotoxic and hypothyroid states. Hypothyroidism impaired the antiproteolytic effects of insulin. Thyroid hormones are, therefore, essential for the normal antiproteolytic action of insulin.
dc.description.firstpage697
dc.description.issuenumber2
dc.description.lastpage706
dc.description.volume85
dc.identifier.doi10.1210/jc.85.2.697
dc.identifier.urihttps://dspace.mackenzie.br/handle/10899/38048
dc.relation.ispartofJournal of Clinical Endocrinology and Metabolism
dc.rightsAcesso Restrito
dc.titleResponse of leucine metabolism to hyperinsulinemia in hypothyroid patients before and after thyroxine replacement
dc.typeArtigo
local.scopus.citations13
local.scopus.eid2-s2.0-17744397295
local.scopus.updated2024-05-01
local.scopus.urlhttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=17744397295&origin=inward
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