Systemic lupus erythematosus activity and beta two microglobulin levels Atividade do lúpus eritematoso sistêmico e níveis de beta dois microglobulina

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dc.contributor.authorSkare T.L.
dc.contributor.authorFerri K.
dc.contributor.authorSantos M.A.
dc.date.accessioned2024-03-13T01:02:12Z
dc.date.available2024-03-13T01:02:12Z
dc.date.issued2014
dc.description.abstractCONTEXT AND OBJECTIVE: Systemic lupus erythematosus (SLE) is an autoimmune disease with a cyclical clinical course. Evaluation of the clinical activity of this disease is important for choosing the correct treatment. The objective of this study was to analyze the value of beta-2 microglobulin (β2M) serum levels in determining SLE clinical activity. DESIGN AND SETTING: Cross-sectional analytical study conducted at the rheumatology outpatient clinic of a private university hospital. METHODS: 129 SLE patients were studied regarding disease activity using SLEDAI (SLE Disease Activity Index) and cumulative damage using SLICC ACR (SLE International Collaborating Clinics/American College of Rheumatology Damage Index for SLE). At the same time, the β2M serum level, ESR (erythrocyte sedimentation rate), anti-dsDNA (anti-double-stranded DNA) and C3 and C4 complement fractions were determined. RESULTS: β2M levels correlated positively with SLEDAI (P = 0.02) and ESR (P = 0.0009) and negatively with C3 (P = 0.007). Patients who were positive for anti-dsDNA had higher β2M serum levels (P = 0.009). CONCLUSION: β2M levels are elevated in SLE patients with active disease.
dc.description.firstpage239
dc.description.issuenumber4
dc.description.lastpage242
dc.description.volume132
dc.identifier.doi10.1590/1516-3180.2014.1324703
dc.identifier.issn1516-3180
dc.identifier.urihttps://dspace.mackenzie.br/handle/10899/36478
dc.relation.ispartofSao Paulo Medical Journal
dc.rightsAcesso Aberto
dc.subject.otherlanguageAcute-phase reaction
dc.subject.otherlanguageBeta 2-microglobulin
dc.subject.otherlanguageBlood sedimentation
dc.subject.otherlanguageInflammation
dc.subject.otherlanguageLupus erythematosus, systemic
dc.titleSystemic lupus erythematosus activity and beta two microglobulin levels Atividade do lúpus eritematoso sistêmico e níveis de beta dois microglobulina
dc.typeArtigo
local.scopus.citations10
local.scopus.eid2-s2.0-84904735864
local.scopus.subjectAdult
local.scopus.subjectbeta 2-Microglobulin
local.scopus.subjectBiological Markers
local.scopus.subjectBlood Sedimentation
local.scopus.subjectC-Reactive Protein
local.scopus.subjectComplement C3
local.scopus.subjectComplement C4
local.scopus.subjectCross-Sectional Studies
local.scopus.subjectFemale
local.scopus.subjectHemoglobins
local.scopus.subjectHumans
local.scopus.subjectLupus Erythematosus, Systemic
local.scopus.subjectMale
local.scopus.subjectMiddle Aged
local.scopus.updated2024-05-01
local.scopus.urlhttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84904735864&origin=inward
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