Systemic lupus erythematosus activity and beta two microglobulin levels Atividade do lúpus eritematoso sistêmico e níveis de beta dois microglobulina
Tipo
Artigo
Data de publicação
2014
Periódico
Sao Paulo Medical Journal
Citações (Scopus)
10
Autores
Skare T.L.
Ferri K.
Santos M.A.
Ferri K.
Santos M.A.
Orientador
Título da Revista
ISSN da Revista
Título de Volume
Membros da banca
Programa
Resumo
CONTEXT AND OBJECTIVE: Systemic lupus erythematosus (SLE) is an autoimmune disease with a cyclical clinical course. Evaluation of the clinical activity of this disease is important for choosing the correct treatment. The objective of this study was to analyze the value of beta-2 microglobulin (β2M) serum levels in determining SLE clinical activity. DESIGN AND SETTING: Cross-sectional analytical study conducted at the rheumatology outpatient clinic of a private university hospital. METHODS: 129 SLE patients were studied regarding disease activity using SLEDAI (SLE Disease Activity Index) and cumulative damage using SLICC ACR (SLE International Collaborating Clinics/American College of Rheumatology Damage Index for SLE). At the same time, the β2M serum level, ESR (erythrocyte sedimentation rate), anti-dsDNA (anti-double-stranded DNA) and C3 and C4 complement fractions were determined. RESULTS: β2M levels correlated positively with SLEDAI (P = 0.02) and ESR (P = 0.0009) and negatively with C3 (P = 0.007). Patients who were positive for anti-dsDNA had higher β2M serum levels (P = 0.009). CONCLUSION: β2M levels are elevated in SLE patients with active disease.
Descrição
Palavras-chave
Assuntos Scopus
Adult , beta 2-Microglobulin , Biological Markers , Blood Sedimentation , C-Reactive Protein , Complement C3 , Complement C4 , Cross-Sectional Studies , Female , Hemoglobins , Humans , Lupus Erythematosus, Systemic , Male , Middle Aged