Gold nanoparticles coupled with graphene quantum dots in organized medium to quantify aminoglycoside anti-biotics in yellow fever vaccine after solid phase extraction using a selective imprinted polymer

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dc.contributor.authorToloza C.A.T.
dc.contributor.authorAlmeida J.M.S.
dc.contributor.authorKhan S.
dc.contributor.authordos Santos Y.G.
dc.contributor.authorda Silva A.R.
dc.contributor.authorRomani E.C.
dc.contributor.authorLarrude D.G.
dc.contributor.authorFreire F.L.
dc.contributor.authorAucelio R.Q.
dc.date.accessioned2024-03-12T23:56:51Z
dc.date.available2024-03-12T23:56:51Z
dc.date.issued2018
dc.description.abstract© 2018 Elsevier B.V.The determination of kanamycin sulfate was made indirectly by measuring its effect on photoluminescent amino functionalized graphene quantum dots (GQDs-amino) associated with gold nanoparticles (AuNPs) that were produced by the reduction of AuCl4 with NaBH4 in an aqueous dispersion of GQDs-amino (obtained by the pyrolysis of citric acid and glutathione) also containing the cationic surfactant CTAB. The AuNPs-GQDs-amino-CTAB system presents a suppressed photoluminescence that is amplified in the presence of kanamycin. Under optimized experimental conditions, the photoluminescence amplification of the nanomaterial system showed a linear response as a function of kanamycin concentration, covering three orders of magnitude (10−7 to 10−5 mol L−1). The use of solid phase extraction with a cartridge packed with aminoglycoside selective molecularly imprinted polymer ensured selectivity in determinations made on yellow-fever vaccine and veterinary pharmaceutical formulations. The analytical results were statistically similar to those obtained with an HPLC-based fluorescence method (after chemical derivatization). The proposed method is a simple, sensitive and selective approach that does not involve the use of toxic reagents employed for chemical derivatization of aminoglycoside antibiotics.
dc.description.firstpage480
dc.description.lastpage493
dc.description.volume158
dc.identifier.doi10.1016/j.jpba.2018.05.050
dc.identifier.issn0731-7085
dc.identifier.urihttps://dspace.mackenzie.br/handle/10899/35473
dc.relation.ispartofJournal of Pharmaceutical and Biomedical Analysis
dc.rightsAcesso Restrito
dc.subject.otherlanguageAmino-functionalized graphene quantum dots
dc.subject.otherlanguageGold nanoparticles
dc.subject.otherlanguageKanamycin sulfate
dc.subject.otherlanguageOrganized medium
dc.subject.otherlanguagePhotoluminescence on/off
dc.titleGold nanoparticles coupled with graphene quantum dots in organized medium to quantify aminoglycoside anti-biotics in yellow fever vaccine after solid phase extraction using a selective imprinted polymer
dc.typeArtigo
local.scopus.citations12
local.scopus.eid2-s2.0-85049112235
local.scopus.subjectAnti-Bacterial Agents
local.scopus.subjectBiosensing Techniques
local.scopus.subjectGold
local.scopus.subjectGraphite
local.scopus.subjectKanamycin
local.scopus.subjectMetal Nanoparticles
local.scopus.subjectPolymers
local.scopus.subjectPreservatives, Pharmaceutical
local.scopus.subjectQuantum Dots
local.scopus.subjectSensitivity and Specificity
local.scopus.subjectSolid Phase Extraction
local.scopus.subjectYellow Fever Vaccine
local.scopus.updated2024-05-01
local.scopus.urlhttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85049112235&origin=inward
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