Structural crystalline characterization of sakuranetin - an antimicrobial flavanone from twigs of baccharis retusa (asteraceae)

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dc.contributor.authorDos S. Grecco S.
dc.contributor.authorDorigueto A.C.
dc.contributor.authorLandre I.M.
dc.contributor.authorSoares M.G.
dc.contributor.authorMartho K.
dc.contributor.authorLima R.
dc.contributor.authorPascon R.C.
dc.contributor.authorVallim M.A.
dc.contributor.authorCapello T.M.
dc.contributor.authorRomoff P.
dc.contributor.authorSartorelli P.
dc.contributor.authorLago J.H.G.
dc.date.accessioned2024-03-13T01:02:20Z
dc.date.available2024-03-13T01:02:20Z
dc.date.issued2014
dc.description.abstractBioactivity-guided fractionation of an antimicrobial active extract from twigs of Baccharis retusa C. DC. (Asteraceae) yielded the flavanone 5,4'-dihydroxy-7-methoxyflavanone (sakuranetin) as responsible for the detected activity. The structure of the bioactive compound was established on the basis of spectroscopic data analysis, including NMR and MS. Additionally, the structure of a new crystal form of sakuranetin was confirmed by X-ray diffratometry. The minimum inhibitory concentrations (MIC) of isolated compound were determined against pathogenic yeast belonging to the genus Candida (six species), Cryptococcus (two species/four serotypes) and S. cerevisiae BY 4742 (S288c background) and ranged from 0.32 to 0.63 μg/μL. Our results showed that sakuranetin, which structure was fully characterized, could be used as a tool for the design of novel and more efficacious antifungal agents. © 2014 by the authors.
dc.description.firstpage7528
dc.description.issuenumber6
dc.description.lastpage7542
dc.description.volume19
dc.identifier.doi10.3390/molecules19067528
dc.identifier.issn1420-3049
dc.identifier.urihttps://dspace.mackenzie.br/handle/10899/36485
dc.relation.ispartofMolecules
dc.rightsAcesso Aberto
dc.subject.otherlanguageAntimicrobial activity
dc.subject.otherlanguageBaccharis retusa
dc.subject.otherlanguageSakuranetin
dc.subject.otherlanguageX-ray diffratometry
dc.titleStructural crystalline characterization of sakuranetin - an antimicrobial flavanone from twigs of baccharis retusa (asteraceae)
dc.typeArtigo
local.scopus.citations27
local.scopus.eid2-s2.0-84903286820
local.scopus.subjectAnti-Infective Agents
local.scopus.subjectAsteraceae
local.scopus.subjectCandida
local.scopus.subjectCryptococcus
local.scopus.subjectFlavonoids
local.scopus.subjectMicrobial Sensitivity Tests
local.scopus.subjectSaccharomyces cerevisiae
local.scopus.updated2024-05-01
local.scopus.urlhttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84903286820&origin=inward
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