Structural crystalline characterization of sakuranetin - an antimicrobial flavanone from twigs of baccharis retusa (asteraceae)
Tipo
Artigo
Data de publicação
2014
Periódico
Molecules
Citações (Scopus)
27
Autores
Dos S. Grecco S.
Dorigueto A.C.
Landre I.M.
Soares M.G.
Martho K.
Lima R.
Pascon R.C.
Vallim M.A.
Capello T.M.
Romoff P.
Sartorelli P.
Lago J.H.G.
Dorigueto A.C.
Landre I.M.
Soares M.G.
Martho K.
Lima R.
Pascon R.C.
Vallim M.A.
Capello T.M.
Romoff P.
Sartorelli P.
Lago J.H.G.
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Resumo
Bioactivity-guided fractionation of an antimicrobial active extract from twigs of Baccharis retusa C. DC. (Asteraceae) yielded the flavanone 5,4'-dihydroxy-7-methoxyflavanone (sakuranetin) as responsible for the detected activity. The structure of the bioactive compound was established on the basis of spectroscopic data analysis, including NMR and MS. Additionally, the structure of a new crystal form of sakuranetin was confirmed by X-ray diffratometry. The minimum inhibitory concentrations (MIC) of isolated compound were determined against pathogenic yeast belonging to the genus Candida (six species), Cryptococcus (two species/four serotypes) and S. cerevisiae BY 4742 (S288c background) and ranged from 0.32 to 0.63 μg/μL. Our results showed that sakuranetin, which structure was fully characterized, could be used as a tool for the design of novel and more efficacious antifungal agents. © 2014 by the authors.
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Assuntos Scopus
Anti-Infective Agents , Asteraceae , Candida , Cryptococcus , Flavonoids , Microbial Sensitivity Tests , Saccharomyces cerevisiae