A nano-magnetic electrochemical sensor for the determination of mood disorder related substances

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dc.contributor.authorCincotto F.H.
dc.contributor.authorCarvalho D.A.S.
dc.contributor.authorCanevari T.C.
dc.contributor.authorToma H.E.
dc.contributor.authorFatibello-Filho O.
dc.contributor.authorMoraes F.C.
dc.date.accessioned2024-03-12T23:59:45Z
dc.date.available2024-03-12T23:59:45Z
dc.date.issued2018
dc.description.abstract© 2018 The Royal Society of Chemistry.The simultaneous electrochemical detection of mood disorder related substances, such as amitriptyline, melatonin and tryptophan, was successfully achieved by using a novel nano-magnetic electrochemical sensor design, encompassing Fe3O4 nanoparticles decorated with carbon quantum dots (MagNPs/Cdots). The magnetic composite was characterized using HR-TEM microscopy, XRD and Raman spectroscopy, and was applied onto a glassy carbon electrode using a miniature neodymium magnet. The determination of amitriptyline, melatonin and tryptophan was performed by monitoring oxidation promoted by MagNPs/Cdots in BR-buffer at pH 3.0, which proceeded according to well-defined differential pulse voltammetry peaks, with detection limits of 5.9, 4.4 and 4.2 nmol L-1, respectively. No significant interference was seen from biological interferents such as uric acid, ascorbic acid, dopamine, estriol and 17β-estradiol. The magnetic hybrid material was highly stable in solution, opening exciting opportunities for the development of low cost and practical electrochemical sensors for the determination of mood disorder related substances in real clinical samples.
dc.description.firstpage14040
dc.description.issuenumber25
dc.description.lastpage14047
dc.description.volume8
dc.identifier.doi10.1039/c8ra01857j
dc.identifier.issn2046-2069
dc.identifier.urihttps://dspace.mackenzie.br/handle/10899/35637
dc.relation.ispartofRSC Advances
dc.rightsAcesso Aberto
dc.titleA nano-magnetic electrochemical sensor for the determination of mood disorder related substances
dc.typeArtigo
local.scopus.citations28
local.scopus.eid2-s2.0-85045740907
local.scopus.subjectCarbon quantum dots
local.scopus.subjectClinical samples
local.scopus.subjectDifferential pulse voltammetry
local.scopus.subjectELectrochemical detection
local.scopus.subjectFe3O4 nanoparticles
local.scopus.subjectGlassy carbon electrodes
local.scopus.subjectMagnetic composites
local.scopus.subjectRelated substances
local.scopus.updated2024-05-01
local.scopus.urlhttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85045740907&origin=inward
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