A nano-magnetic electrochemical sensor for the determination of mood disorder related substances
Tipo
Artigo
Data de publicação
2018
Periódico
RSC Advances
Citações (Scopus)
28
Autores
Cincotto F.H.
Carvalho D.A.S.
Canevari T.C.
Toma H.E.
Fatibello-Filho O.
Moraes F.C.
Carvalho D.A.S.
Canevari T.C.
Toma H.E.
Fatibello-Filho O.
Moraes F.C.
Orientador
Título da Revista
ISSN da Revista
Título de Volume
Membros da banca
Programa
Resumo
© 2018 The Royal Society of Chemistry.The simultaneous electrochemical detection of mood disorder related substances, such as amitriptyline, melatonin and tryptophan, was successfully achieved by using a novel nano-magnetic electrochemical sensor design, encompassing Fe3O4 nanoparticles decorated with carbon quantum dots (MagNPs/Cdots). The magnetic composite was characterized using HR-TEM microscopy, XRD and Raman spectroscopy, and was applied onto a glassy carbon electrode using a miniature neodymium magnet. The determination of amitriptyline, melatonin and tryptophan was performed by monitoring oxidation promoted by MagNPs/Cdots in BR-buffer at pH 3.0, which proceeded according to well-defined differential pulse voltammetry peaks, with detection limits of 5.9, 4.4 and 4.2 nmol L-1, respectively. No significant interference was seen from biological interferents such as uric acid, ascorbic acid, dopamine, estriol and 17β-estradiol. The magnetic hybrid material was highly stable in solution, opening exciting opportunities for the development of low cost and practical electrochemical sensors for the determination of mood disorder related substances in real clinical samples.
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Assuntos Scopus
Carbon quantum dots , Clinical samples , Differential pulse voltammetry , ELectrochemical detection , Fe3O4 nanoparticles , Glassy carbon electrodes , Magnetic composites , Related substances