Development of methodology for the synthesis of poly(lactic acid-co-glycolic acid) for use in the production of radioactive sources Desenvolvimento da metodologia para síntese do poli(ácido lático-co-ácido glicólico) para utilização na produção de fontes radioativas

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dc.contributor.authorDos Santos Peleias F.
dc.contributor.authorZeituni C.A.
dc.contributor.authorRostelato M.E.C.M.
dc.contributor.authorFechine G.J.M.
dc.contributor.authorDe Souza C.D.
dc.contributor.authorDe Mattos F.R.
dc.contributor.authorDe Moura E.S.
dc.contributor.authorMoura J.A.
dc.contributor.authorBenega M.A.G.
dc.contributor.authorFeher A.
dc.contributor.authorDa Costa O.L.
dc.contributor.authorRodrigues B.T.
dc.date.accessioned2024-03-13T00:59:07Z
dc.date.available2024-03-13T00:59:07Z
dc.date.issued2015
dc.description.abstractAccording to the World Health Organization, cancer is a leading cause of death worldwide. A radiotherapy method extensively used in prostate cancer is brachytherapy, where the area requiring treatment receives radioactive seeds. Iodine-125 seeds can be inserted loose or stranded in bioabsorbable polymers produced from poly(lactic-co-glycolic acid) (PLGA). We developed the synthesis methodology for PLGA and the results obtained show that it was possible to determine the optimal reaction parameters (time and temperature) for PLGA in 80/20 (lactide/glycolide) ratio. The yield was higher than 90% using a temperature of 110°C and reaction time of 72 hours; however, the molecular weight values obtained are very low compared to those obtained by other authors. New tests using previously synthesized dimers and nitrogen atmosphere are being performed. These conditions could potentially increase the molar mass of PLGA. All techniques used confirmed the expected structure of the polymer.
dc.description.firstpage317
dc.description.issuenumber3
dc.description.lastpage325
dc.description.volume25
dc.identifier.doi10.1590/0104-1428.1428
dc.identifier.issn0104-1428
dc.identifier.urihttps://dspace.mackenzie.br/handle/10899/36307
dc.relation.ispartofPolimeros
dc.rightsAcesso Aberto
dc.subject.otherlanguageBrachytherapy
dc.subject.otherlanguagePLGA
dc.subject.otherlanguagePoly(lactic-co-glycolic acid)
dc.subject.otherlanguageProstate cancer
dc.titleDevelopment of methodology for the synthesis of poly(lactic acid-co-glycolic acid) for use in the production of radioactive sources Desenvolvimento da metodologia para síntese do poli(ácido lático-co-ácido glicólico) para utilização na produção de fontes radioativas
dc.typeArtigo
local.scopus.citations2
local.scopus.eid2-s2.0-84940109450
local.scopus.subjectBioabsorbable polymer
local.scopus.subjectBrachytherapy
local.scopus.subjectPLGA
local.scopus.subjectPoly lactic-co-glycolic acid
local.scopus.subjectPoly(lactic acid-co-glycolic acid)
local.scopus.subjectProstate cancers
local.scopus.subjectStructure of the polymers
local.scopus.subjectWorld Health Organization
local.scopus.updated2024-05-01
local.scopus.urlhttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84940109450&origin=inward
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