Development of methodology for the synthesis of poly(lactic acid-co-glycolic acid) for use in the production of radioactive sources Desenvolvimento da metodologia para síntese do poli(ácido lático-co-ácido glicólico) para utilização na produção de fontes radioativas
Tipo
Artigo
Data de publicação
2015
Periódico
Polimeros
Citações (Scopus)
2
Autores
Dos Santos Peleias F.
Zeituni C.A.
Rostelato M.E.C.M.
Fechine G.J.M.
De Souza C.D.
De Mattos F.R.
De Moura E.S.
Moura J.A.
Benega M.A.G.
Feher A.
Da Costa O.L.
Rodrigues B.T.
Zeituni C.A.
Rostelato M.E.C.M.
Fechine G.J.M.
De Souza C.D.
De Mattos F.R.
De Moura E.S.
Moura J.A.
Benega M.A.G.
Feher A.
Da Costa O.L.
Rodrigues B.T.
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Título de Volume
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Resumo
According to the World Health Organization, cancer is a leading cause of death worldwide. A radiotherapy method extensively used in prostate cancer is brachytherapy, where the area requiring treatment receives radioactive seeds. Iodine-125 seeds can be inserted loose or stranded in bioabsorbable polymers produced from poly(lactic-co-glycolic acid) (PLGA). We developed the synthesis methodology for PLGA and the results obtained show that it was possible to determine the optimal reaction parameters (time and temperature) for PLGA in 80/20 (lactide/glycolide) ratio. The yield was higher than 90% using a temperature of 110°C and reaction time of 72 hours; however, the molecular weight values obtained are very low compared to those obtained by other authors. New tests using previously synthesized dimers and nitrogen atmosphere are being performed. These conditions could potentially increase the molar mass of PLGA. All techniques used confirmed the expected structure of the polymer.
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Assuntos Scopus
Bioabsorbable polymer , Brachytherapy , PLGA , Poly lactic-co-glycolic acid , Poly(lactic acid-co-glycolic acid) , Prostate cancers , Structure of the polymers , World Health Organization