Análise da presença de HPV por imunorreatividade para P16 em hemorróidas externas
Tipo
TCC
Data de publicação
2023-11-27
Periódico
Citações (Scopus)
Autores
Fujiki, Julia Yumi
Lopes , Laura Mendes
Lopes , Laura Mendes
Orientador
Sobral , Ana Cristina Lira
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ISSN da Revista
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Resumo
INTRODUÇÃO: O Papiloma Vírus Humano (HPV) é considerado a infecção sexualmente transmissível com maior prevalência na população, podendo conduzir o tecido epitelial a expressar fenômenos neoplásicos. Devido à predileção do HPV por epitélio estratificado, o vírus também pode se manifestar em tecido hemorroidário, evidenciando a importância de uma cuidadosa avaliação do tecido removido durante a hemorroidectomia. OBJETIVO: Avaliar a presença do HPV no tecido hemorroidário externo, bem como avaliar a incidência do HPV em hemorroidas externa por faixas etárias e sexo. METODOLOGIA: Estudo retrospectivo observacional com análise imuno-histoquímica com anticorpo P16 para verificar a presença de HPV no tecido hemorroidário de 44 pacientes. RESULTADO: Dos 44 pacientes analisados, 26 eram do sexo feminino e 18 do sexo masculino, sendo que 84% dos pacientes possuíam 36 anos ou mais. Os pacientes que apresentaram positividade têm em média 51,62 anos, e os pacientes que não apresentaram positividade tem em média 45,35 anos, não havendo diferença significativa entre os grupos (p=0,13). Apesar de 54% dos pacientes do sexo feminino terem apresentado positividade frente a 39% do sexo masculino, essa diferença não foi estatisticamente significativa (p=0,33). CONCLUSÃO: Dos pacientes submetidos a hemorroidectomia com alterações similares a coilócitos, cerca de metade expressava HPV, podendo beneficiar-se, portanto, de um acompanhamento e pesquisa para HPV a fim de detectar lesões pré-cancerosas.
INTRODUCTION: Human Papillomavirus (HPV) is considered the most prevalent sexually transmitted disease in the population, being able to induce the expression of neoplastic phenomenon on epithelial cells. Due to its predilection for stratified tissue, it can manifest itself on hemorrhoids, showing the importance of a careful evaluation of the tissue removed in the hemorrhoidectomy. OBJECTIVE: Evaluate the presence of HPV in the hemorrhoidal tissue removed during hemorrhoidectomy and estimate the incidence of HPV on external hemorrhoids by age and sex as well. METHODS: Observational retrospective study with immunohistochemistry analysis with P16 antibodies to verify the presence of HPV in hemorrhoidal tissue of 44 patients. RESULTS: Of the 44 cases analyzed, 26 were female and 84% of the patients had the age of 36 years or more. The patients that had HPV found on tissue had a mean age of 51,62 years and for the counterpart a mean of 45,35 years. not showing significant difference between the groups (p=0,13). Although the female group had a positivity of 54% compared to the 39% of the male group, it didn’t result in any significant difference between them (p=0,33). CONCLUSION: Approximately half of the patients that had koilocytes expressed the presence of HPV on the same tissue. This infers that it could be beneficial to have a follow-up and search of HPV on the intention of detecting precancerous lesions.
INTRODUCTION: Human Papillomavirus (HPV) is considered the most prevalent sexually transmitted disease in the population, being able to induce the expression of neoplastic phenomenon on epithelial cells. Due to its predilection for stratified tissue, it can manifest itself on hemorrhoids, showing the importance of a careful evaluation of the tissue removed in the hemorrhoidectomy. OBJECTIVE: Evaluate the presence of HPV in the hemorrhoidal tissue removed during hemorrhoidectomy and estimate the incidence of HPV on external hemorrhoids by age and sex as well. METHODS: Observational retrospective study with immunohistochemistry analysis with P16 antibodies to verify the presence of HPV in hemorrhoidal tissue of 44 patients. RESULTS: Of the 44 cases analyzed, 26 were female and 84% of the patients had the age of 36 years or more. The patients that had HPV found on tissue had a mean age of 51,62 years and for the counterpart a mean of 45,35 years. not showing significant difference between the groups (p=0,13). Although the female group had a positivity of 54% compared to the 39% of the male group, it didn’t result in any significant difference between them (p=0,33). CONCLUSION: Approximately half of the patients that had koilocytes expressed the presence of HPV on the same tissue. This infers that it could be beneficial to have a follow-up and search of HPV on the intention of detecting precancerous lesions.
Descrição
Palavras-chave
hemorroidas , infecções por papillomavirus , imuno-histoquímica , hemorrhoids , papillomavirus infection , immunohistochemistry