Liberação controlada de bioativos suportados por nanopartículas de pseudoboemita obtidas pelo processo sol-gel

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dc.contributor.advisorMiranda, Leila Figueiredo de
dc.contributor.advisor1Latteshttp://lattes.cnpq.br/0218222413589119por
dc.contributor.authorBarbosa, Isabella Tereza Ferro
dc.creator.Latteshttp://lattes.cnpq.br/8053445848637533por
dc.date.accessioned2021-12-15T19:31:40Z
dc.date.available2021-12-15T19:31:40Z
dc.date.issued2019-11-06
dc.description.abstractThe use of hydrogels combined with various additives in tissue regeneration, injuries and burns has been an option in anti-aging treatments. Poly (N-vinyl-2-pyrrolidone) based hydrogels form an effective barrier against external bacteria, although they allow the passage of oxygen and cosmetic assets because they are permeable to them. The pseudoboehmites obtained by the sol-gel process are nanoparticles with high surface area, besides having expressive absorption properties, which can adsorb large concentration of actives and these are gradually released in an aqueous medium. The aim of the study was to obtain nanoemulsion hydrogels containing pseudoboehmite, essential oil and vegetable nanoparticles carrying long-acting active ingredients without the use of preservatives. In this work, several PVP-based hydrogels (10%, 7%, 5% weight) containing nanoemulsions with palmarosa essential oil, rosehip vegetable oil, mandellic acid, hyaluronic acid and pseudoboehmite nanoparticles (1%, 3% e 5% weight) were obtained and characterized. The hydrogels were obtained by ionizing radiation with 25kGy dose. The characterization of the hydrogels was performed by visual characterization, sensory aspects, dehydration as a function of time, isothermal density with air drag, pH, density, thermal analysis, optical microscopy, skin biometric assays, UV-Vis electron spectroscopy and microscopy scanning electronics. The results showed the possibility of obtaining a cosmetic product, PVP based hydrogel containing pseudoboehmite / mandellic acid nanoemulsion, pseudoboehmite / hyaluronic acid nanoemulsion, palmarosa essential oil and rosehip vegetable oil without the use of preservatives, kept sterile by the action of ionizing radiation. The hydrogel containing rosehip vegetable oil, 3wt% pseudoboemite, 2.1wt% mandellic acid, palmarosa essential oil, 1wt% pseudoboemite and 2.1wt% hyaluronic acid was the most suitable for obtaining an anti-aging cosmetic.eng
dc.description.sponsorshipCoordenação de Aperfeiçoamento de Pessoal de Nível Superiorpor
dc.description.sponsorshipInstituto Presbiteriano Mackenziepor
dc.formatapplication/pdf*
dc.identifier.citationBARBOSA, Isabella Tereza Ferro. Liberação controlada de bioativos suportados por nanopartículas de pseudoboemita obtidas pelo processo sol-gel. 2019. 209 f. Tese (doutorado em Engenharia de Materiais e Nanotecnologia) - Universidade Presbiteriana Mackenzie, São Paulo, 2019.por
dc.identifier.urihttps://dspace.mackenzie.br/handle/10899/28436
dc.keywordsnanotechnologyeng
dc.keywordspseudoboehmiteeng
dc.keywordsmandellic acideng
dc.keywordshyaluronic acid.eng
dc.languageporpor
dc.publisherUniversidade Presbiteriana Mackenziepor
dc.rightsAcesso Abertopor
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/
dc.subjectnanotecnologiapor
dc.subjectpseudoboemitapor
dc.subjectácido mandélicopor
dc.subjectácido hialurônicopor
dc.subject.cnpqCNPQ::ENGENHARIAS::ENGENHARIA DE MINASpor
dc.titleLiberação controlada de bioativos suportados por nanopartículas de pseudoboemita obtidas pelo processo sol-gelpor
dc.typeTesepor
local.contributor.board1Munhoz Junior, Antonio Hortêncio
local.contributor.board2Ribeiro, Roberto Rodrigues
local.contributor.board3Seo, Emília Satoshi Miyamaru
local.contributor.board4Sarmento, Bruno Filipe Carmelino Cardoso
local.publisher.countryBrasilpor
local.publisher.departmentEscola de Engenharia Mackenzie (EE)por
local.publisher.initialsUPMpor
local.publisher.programEngenharia de Materiais e Nanotecnologiapor
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