Multisensory Stimulation Improves Cognition and Behavior in Adult Male Rats Born to LT4-treated Thyroidectomized Dams

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dc.contributor.authorBatistuzzo A.
dc.contributor.authorDe Almeida G.G.
dc.contributor.authorBras T.S.
dc.contributor.authorZucato V.P.
dc.contributor.authorArnold A.J.T.
dc.contributor.authorGiannocco G.
dc.contributor.authorSato J.M.
dc.contributor.authorYamanouchi L.M.
dc.contributor.authorDias E.
dc.contributor.authorLorena F.B.
dc.contributor.authorDo Nascimento B.P.P.
dc.contributor.authorBianco A.C.
dc.contributor.authorRibeiro M.O.
dc.date.accessioned2024-03-12T19:14:06Z
dc.date.available2024-03-12T19:14:06Z
dc.date.issued2022
dc.description.abstract© 2022 The Author(s). Published by Oxford University Press on behalf of the Endocrine Society. All rights reserved. Gestational hypothyroidism can impair development, cognition, and mood. Here, we tested whether multisensory stimulation (MS) improves the phenotype of rats born to surgically thyroidectomized (Tx) dams suboptimally treated with LT4. 8-week-old female Tx Wistar rats were kept on daily LT4 (0.7 μg/100 g body weight) dosed by gavage (serum TSH and T4 levels indicated moderate hypothyroidism) and 3 weeks later placed for breeding. MS of the litter started at age 60 days and lasted for 8 weeks. It consisted of twice per week of physical, cognitive, sensorial, and food stimuli. The offspring were assessed before and after MS for standardized tests of locomotor activity, cognition, and mood. Gestational hypothyroidism resulted in reduced litter size and increased offspring mortality. The pups exhibited delayed physical development, impairment of short- A nd long-term memory, and anxiety- A nd depressive-like behaviors. Nonetheless, ambulatory activity, social memory, and social preference were not affected by gestational hypothyroidism. MS restored short-term memory and anxiety while improving depressive like-behaviors. MS did not improve long-term memory. MS also did not modify the performance of control litter born to intact dams. We conclude that cognition and mood impairments caused by moderate gestational hypothyroidism were reversed or minimized in rats through MS. Further studies should define the molecular mechanisms involved.
dc.description.issuenumber9
dc.description.volume163
dc.identifier.doi10.1210/endocr/bqac105
dc.identifier.issn1945-7170
dc.identifier.urihttps://dspace.mackenzie.br/handle/10899/34316
dc.relation.ispartofEndocrinology (United States)
dc.rightsAcesso Restrito
dc.subject.otherlanguagebehavior
dc.subject.otherlanguagegestational hypothyroidism
dc.subject.otherlanguagememory
dc.subject.otherlanguagemultisensory stimulation
dc.titleMultisensory Stimulation Improves Cognition and Behavior in Adult Male Rats Born to LT4-treated Thyroidectomized Dams
dc.typeArtigo
local.scopus.citations4
local.scopus.eid2-s2.0-85135598358
local.scopus.subjectAnimals
local.scopus.subjectCognition
local.scopus.subjectFemale
local.scopus.subjectHypothyroidism
local.scopus.subjectMale
local.scopus.subjectParturition
local.scopus.subjectPregnancy
local.scopus.subjectRats
local.scopus.subjectRats, Wistar
local.scopus.subjectThyroxine
local.scopus.updated2024-12-01
local.scopus.urlhttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85135598358&origin=inward
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