Biocatalysis for desymmetrization and resolution of stereocenters beyond the reactive center: How far is far enough?

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dc.contributor.authorCunha R.L.O.R.
dc.contributor.authorFerreira E.A.
dc.contributor.authorOliveira C.S.
dc.contributor.authorOmori A.T.
dc.date.accessioned2024-03-13T00:56:34Z
dc.date.available2024-03-13T00:56:34Z
dc.date.issued2015
dc.description.abstract© 2014 Elsevier Inc.The kinetic resolution of racemates and desymmetrization are the most common approaches to the preparation of enantiomerically enriched compounds. These procedures allow the access of high valuable, chiral building blocks for many purposes in academic or industrial R&D endeavors. Nevertheless, the scope of stereochemistry recognition in biotransformations usually occurs at the site of the transformation or when it is close to it (not more than 3 bonds). However, there are a growing number of enzymatic transformations which surpass the limits of stereorecognition of remote chiral (or prochiral) centers. In this account, we would like to present some aspects of biocatalyzed remote resolutions and remote desymmetrizations to call attention for these challenging transformations.
dc.description.firstpage614
dc.description.issuenumber5
dc.description.lastpage623
dc.description.volume33
dc.identifier.doi10.1016/j.biotechadv.2014.12.009
dc.identifier.issn0734-9750
dc.identifier.urihttps://dspace.mackenzie.br/handle/10899/36162
dc.relation.ispartofBiotechnology Advances
dc.rightsAcesso Restrito
dc.subject.otherlanguageDesymmetrization
dc.subject.otherlanguageHydrolases
dc.subject.otherlanguageKinetic resolution
dc.subject.otherlanguageRemote resolution
dc.subject.otherlanguageRemote stereocontrol
dc.titleBiocatalysis for desymmetrization and resolution of stereocenters beyond the reactive center: How far is far enough?
dc.typeArtigo de revisão
local.scopus.citations20
local.scopus.eid2-s2.0-84931006211
local.scopus.subjectBiocatalysis
local.scopus.subjectChiral building blocks
local.scopus.subjectDesym-metrization
local.scopus.subjectEnzymatic transformation
local.scopus.subjectKinetic resolution
local.scopus.subjectKinetic resolution of racemates
local.scopus.subjectRemote stereocontrol
local.scopus.subjectStereocenters
local.scopus.subjectBiocatalysis
local.scopus.subjectBiochemistry
local.scopus.subjectHydrolases
local.scopus.subjectKinetics
local.scopus.subjectStereoisomerism
local.scopus.updated2024-05-01
local.scopus.urlhttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84931006211&origin=inward
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