Biocatalysis for desymmetrization and resolution of stereocenters beyond the reactive center: How far is far enough?
Tipo
Artigo de revisão
Data de publicação
2015
Periódico
Biotechnology Advances
Citações (Scopus)
20
Autores
Cunha R.L.O.R.
Ferreira E.A.
Oliveira C.S.
Omori A.T.
Ferreira E.A.
Oliveira C.S.
Omori A.T.
Orientador
Título da Revista
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Título de Volume
Membros da banca
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Resumo
© 2014 Elsevier Inc.The kinetic resolution of racemates and desymmetrization are the most common approaches to the preparation of enantiomerically enriched compounds. These procedures allow the access of high valuable, chiral building blocks for many purposes in academic or industrial R&D endeavors. Nevertheless, the scope of stereochemistry recognition in biotransformations usually occurs at the site of the transformation or when it is close to it (not more than 3 bonds). However, there are a growing number of enzymatic transformations which surpass the limits of stereorecognition of remote chiral (or prochiral) centers. In this account, we would like to present some aspects of biocatalyzed remote resolutions and remote desymmetrizations to call attention for these challenging transformations.
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Assuntos Scopus
Biocatalysis , Chiral building blocks , Desym-metrization , Enzymatic transformation , Kinetic resolution , Kinetic resolution of racemates , Remote stereocontrol , Stereocenters , Biocatalysis , Biochemistry , Hydrolases , Kinetics , Stereoisomerism