Serum cytokine levels and acute graft-versus-host disease after HLA-identical hematopoietic stem cell transplantation

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dc.contributor.authorVisentainer J.E.L.
dc.contributor.authorLieber S.R.
dc.contributor.authorPersoli L.B.L.
dc.contributor.authorVigorito A.C.
dc.contributor.authorAranha F.J.P.
dc.contributor.authorDe Brito Eid K.A.
dc.contributor.authorOliveira G.B.
dc.contributor.authorMiranda E.C.M.
dc.contributor.authorDe Souza C.A.
dc.date.accessioned2024-03-13T01:46:05Z
dc.date.available2024-03-13T01:46:05Z
dc.date.issued2003
dc.description.abstractObjective. The aim of this study was to investigate whether the serum levels of soluble interleukin-2R (sIL-2R), tumor necrosis factor-α (TNF-α), interferon-γ (IFN-γ), IL-6, IL-10, and transforming growth factor-β1 (TGF-β1) were associated with the development of acute graft-vs-host disease (aGVHD). Patients and Methods. Serum cytokine levels were sequentially measured by sandwich enzyme-linked immunosorbent assay in 13 patients who had received full-match allogeneic hematopoietic stem cell transplantation (HSCT). Results. Serum sIL-2R and IL-10 levels from the 1st to the 15th week post transplantation were significantly higher in the group that developed aGVHD than in the group without aGVHD. sIL-2R levels increased in direct correlation to engraftment and at onset of aGVHD, whereas IL-10 levels increased transiently following HSCT. The mean TNF-α concentration in the first weeks after transplantation was augmented in the group that developed aGVHD. Furthermore, a decrease in TGF-β1 levels after engraftment was significantly associated with aGVHD. No correlation was found between aGVHD and the other cytokines. Conclusions. These results support the idea that a balance between cytokines derived from type 1 and type 2 T-helper cells may be important in the development and control of aGVHD. Although sIL-2R, TNF-α, IL-10, and TGF-β1 levels have been correlated with aGVHD, sIL-2R levels at engraftment may provide a better parameter for early detection of aGVHD after allogeneic HSCT. © 2003 International Society for Experimental Hematology. Published by Elsevier Inc.
dc.description.firstpage1044
dc.description.issuenumber11
dc.description.lastpage1050
dc.description.volume31
dc.identifier.doi10.1016/S0301-472X(03)00264-9
dc.identifier.urihttps://dspace.mackenzie.br/handle/10899/37989
dc.relation.ispartofExperimental Hematology
dc.rightsAcesso Restrito
dc.titleSerum cytokine levels and acute graft-versus-host disease after HLA-identical hematopoietic stem cell transplantation
dc.typeArtigo
local.scopus.citations83
local.scopus.eid2-s2.0-0142258092
local.scopus.updated2024-05-01
local.scopus.urlhttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=0142258092&origin=inward
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