Withanolides from Aureliana fasciculata var. fasciculata
Tipo
Artigo
Data de publicação
2010
Periódico
Helvetica Chimica Acta
Citações (Scopus)
16
Autores
Almeida-Lafeta R.C.
Ferreira M.J.P.
Emerenciano V.P.
Kaplan M.A.C.
Ferreira M.J.P.
Emerenciano V.P.
Kaplan M.A.C.
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Resumo
In the first phytochemical study of the Aureliana genus (Solanaceae), two new withanolides, 1 and 2, together with two known sterols, were isolated from the MeOH extract of the leaves of Aureliana fasciculata var. fasciculata. The structures were established as (4S,22R)-16α-acetoxy-5β,6β-epoxy- 4β,17α-dihydroxy-1-oxowitha-2,24-dienolide (aurelianolide A) and (4S,22R)-16α-acetoxy-4β,17α-dihydroxy-1-oxowitha-2,5, 24-trienolide (aurelianolide B). The new compounds possessed the unusual 16α,17α-dioxygenated group and were fully characterized by spectroscopic techniques, including 1H- and 13C-NMR (DEPT), as well as 2D-NMR (HMBC, HMQC, 1H,1H-COSY, NOESY) experiments, and HR-MS. © 2010 Verlag Helvetica Chimica Acta AG, Zürich.
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Assuntos Scopus
Aureliana fasciculata var. fasciculata , Aurelianolides A and B , Solanaceae , Spectroscopic technique , Withanolides