A relação entre o helicobacter pylori e as pequenas epitelizações colunares do esôfago distal com ou sem metaplasia intestinal
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Tipo
Dissertação
Data de publicação
2019-01-11
Periódico
Citações (Scopus)
Autores
Degiovani, Matheus
Orientador
Ribas, Carmen Australia Paredes Marcondes
Título da Revista
ISSN da Revista
Título de Volume
Membros da banca
Tabushi, Fernando Issamu
Giovanini, Allan Fernando
Collaço, Luiz Martins
Giovanini, Allan Fernando
Collaço, Luiz Martins
Programa
Princípios da Cirurgia
Resumo
Introduction: The presence of intestinal metaplasia in the distal esophagus
(Barrett's esophagus) is an important precursor of adenocarcinoma. Knowledge of
the risk factors and the process by which the Barrett develops is very importance and
H.pylori can contribute to this development. Objective: To analyze the impact of H.
pylori in the gastric mucosa of intestinal metaplasia in the distal esophagus in areas
of columnar epithelialization smaller than 10 mm in length, stratified for gender and
age. Method: A retrospective study in which were included 373 consecutive patients
diagnosed with columnar epithelium in the distal esophagus. In all it was searched
the H.pylori by two methods (urease and histology) and applied the inclusion and
exclusion factors. It is divided into two groups: the first adding patients without
histological diagnosis of Barrett's esophagus (235-63%) and the second comprising
the histologically diagnosed with Barrett's esophagus (138-37%). Results: There
was no significant difference between the carriers of H. pylori or not in relation to the
likelihood of having intestinal metaplasia (p = 0.587). When related to the general
group, there was an inverse association between the bacteria and the columnar
epithelialization in the distal esophagus. Age (p = 0.031), gender (p = 0.013) and H.
pylori (p = 0.613) when connected together to intestinal metaplasia showed no
significant relationship. In isolation; when related age and gender, regardless of H.
pylori emerged results confirming that older patients and women have a higher
incidence of intestinal metaplasia (Barrett's esophagus). Conclusion: The presence
or absence of intestinal metaplasia of distal esophagus when related to H. pylori in
the gastric mucosa, is not significant. In relation to age and gender, regardless of
H.pylori, we note that in women and the greater the age of the individuals, there is an
increase in the number of cases with intestinal metaplasia in the distal esophagus.
Descrição
Palavras-chave
esôfago de Barrett , helicobacter pylori , etaplasia
Assuntos Scopus
Citação
DEGIOVANI, Matheus. A relação entre o helicobacter pylori e as pequenas epitelizações colunares do esôfago distal com ou sem metaplasia intestinal. 2019. 51 p. Dissertação (Mestrado em Princípios da Cirurgia) - Faculdade Evangélica Mackenzie do Paraná ,Curitiba, 2019