Alcohol consumption and sudden unexpected death in epilepsy: Experimental approach

Página do item simplificado
dc.contributor.authorScorza C.A.
dc.contributor.authorCysneiros R.M.
dc.contributor.authorArida R.M.
dc.contributor.authorTerra V.C.
dc.contributor.authorMachado H.R.
dc.contributor.authorDe Almeida A.-C.G.
dc.contributor.authorCavalheiro E.A.
dc.contributor.authorScorza F.A.
dc.date.accessioned2024-03-13T01:35:47Z
dc.date.available2024-03-13T01:35:47Z
dc.date.issued2009
dc.description.abstractUsing the pilocarpine model of epilepsy, we investigated the effects of alcohol consumption on the frequency of seizures in animals with epilepsy as well the underlying a possible association between alcohol intake and sudden unexpected death in epilepsy (SUDEP) occurrence. Rats were divided randomly into two groups: (A) rats with epilepsy and (B) rats with epilepsy that received a daily dose of ethanol solution (350 mg kg-1, i.p.) for 30 days. The basal frequency of seizures observed in the A and B groups during the first 30 days were 3.4±1.5 and 3.2±1.9 seizures per week per animal, respectively. In B group, it was observed a significant seizure increase (11.6±5.3) during the first 2 weeks of alcohol administration and quite interesting, one rat died suddenly after a generalized tonic-clonic seizure during this period. We concluded in our experimental study that exist a possible association between alcohol abuse and SUDEP occurrence.
dc.description.firstpage1003
dc.description.issuenumber4
dc.description.lastpage1006
dc.description.volume67
dc.identifier.doi10.1590/S0004-282X2009000600008
dc.identifier.issn1678-4227
dc.identifier.urihttps://dspace.mackenzie.br/handle/10899/37422
dc.relation.ispartofArquivos de Neuro-Psiquiatria
dc.rightsAcesso Aberto
dc.subject.otherlanguageAlcohol
dc.subject.otherlanguageEpilepsy
dc.subject.otherlanguageHeart
dc.subject.otherlanguageSeizure
dc.subject.otherlanguageSUDEP
dc.titleAlcohol consumption and sudden unexpected death in epilepsy: Experimental approach
dc.typeArtigo
local.scopus.citations5
local.scopus.eid2-s2.0-76149111166
local.scopus.updated2024-05-01
local.scopus.urlhttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=76149111166&origin=inward
Arquivos
Coleções
Artigos de periódico