Alcohol consumption and sudden unexpected death in epilepsy: Experimental approach
dc.contributor.author | Scorza C.A. | |
dc.contributor.author | Cysneiros R.M. | |
dc.contributor.author | Arida R.M. | |
dc.contributor.author | Terra V.C. | |
dc.contributor.author | Machado H.R. | |
dc.contributor.author | De Almeida A.-C.G. | |
dc.contributor.author | Cavalheiro E.A. | |
dc.contributor.author | Scorza F.A. | |
dc.date.accessioned | 2024-03-13T01:35:47Z | |
dc.date.available | 2024-03-13T01:35:47Z | |
dc.date.issued | 2009 | |
dc.description.abstract | Using the pilocarpine model of epilepsy, we investigated the effects of alcohol consumption on the frequency of seizures in animals with epilepsy as well the underlying a possible association between alcohol intake and sudden unexpected death in epilepsy (SUDEP) occurrence. Rats were divided randomly into two groups: (A) rats with epilepsy and (B) rats with epilepsy that received a daily dose of ethanol solution (350 mg kg-1, i.p.) for 30 days. The basal frequency of seizures observed in the A and B groups during the first 30 days were 3.4±1.5 and 3.2±1.9 seizures per week per animal, respectively. In B group, it was observed a significant seizure increase (11.6±5.3) during the first 2 weeks of alcohol administration and quite interesting, one rat died suddenly after a generalized tonic-clonic seizure during this period. We concluded in our experimental study that exist a possible association between alcohol abuse and SUDEP occurrence. | |
dc.description.firstpage | 1003 | |
dc.description.issuenumber | 4 | |
dc.description.lastpage | 1006 | |
dc.description.volume | 67 | |
dc.identifier.doi | 10.1590/S0004-282X2009000600008 | |
dc.identifier.issn | 1678-4227 | |
dc.identifier.uri | https://dspace.mackenzie.br/handle/10899/37422 | |
dc.relation.ispartof | Arquivos de Neuro-Psiquiatria | |
dc.rights | Acesso Aberto | |
dc.subject.otherlanguage | Alcohol | |
dc.subject.otherlanguage | Epilepsy | |
dc.subject.otherlanguage | Heart | |
dc.subject.otherlanguage | Seizure | |
dc.subject.otherlanguage | SUDEP | |
dc.title | Alcohol consumption and sudden unexpected death in epilepsy: Experimental approach | |
dc.type | Artigo | |
local.scopus.citations | 5 | |
local.scopus.eid | 2-s2.0-76149111166 | |
local.scopus.updated | 2024-05-01 | |
local.scopus.url | https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=76149111166&origin=inward |