Alcohol consumption and sudden unexpected death in epilepsy: Experimental approach

Tipo
Artigo
Data de publicação
2009
Periódico
Arquivos de Neuro-Psiquiatria
Citações (Scopus)
5
Autores
Scorza C.A.
Cysneiros R.M.
Arida R.M.
Terra V.C.
Machado H.R.
De Almeida A.-C.G.
Cavalheiro E.A.
Scorza F.A.
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Resumo
Using the pilocarpine model of epilepsy, we investigated the effects of alcohol consumption on the frequency of seizures in animals with epilepsy as well the underlying a possible association between alcohol intake and sudden unexpected death in epilepsy (SUDEP) occurrence. Rats were divided randomly into two groups: (A) rats with epilepsy and (B) rats with epilepsy that received a daily dose of ethanol solution (350 mg kg-1, i.p.) for 30 days. The basal frequency of seizures observed in the A and B groups during the first 30 days were 3.4±1.5 and 3.2±1.9 seizures per week per animal, respectively. In B group, it was observed a significant seizure increase (11.6±5.3) during the first 2 weeks of alcohol administration and quite interesting, one rat died suddenly after a generalized tonic-clonic seizure during this period. We concluded in our experimental study that exist a possible association between alcohol abuse and SUDEP occurrence.
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