Fish oil supplementation reduces heart levels of interleukin-6 in rats with chronic inflammation due to epilepsy

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dc.contributor.authorNejm M.B.
dc.contributor.authorHaidar A.A.
dc.contributor.authorHirata A.E.
dc.contributor.authorOyama L.M.
dc.contributor.authorde Almeida A.G.
dc.contributor.authorCysneiros R.M.
dc.contributor.authorCavalheiro E.A.
dc.contributor.authorScorza C.A.
dc.contributor.authorScorza F.A.
dc.date.accessioned2024-03-13T00:49:22Z
dc.date.available2024-03-13T00:49:22Z
dc.date.issued2017
dc.description.abstract© 2017 Nejm, Haidar, Hirata, Oyama, de Almeida, Cysneiros, Cavalheiro, Scorza and Scorza.Sudden unexpected death in epilepsy (SUDEP) is a major cause of premature death related to epilepsy. The causes of SUDEP remain unknown, but cardiac arrhythmias and asphyxia have been suggested as a major mechanism of this event. Inflammation has been implicated in the pathogenesis of both epilepsy and ventricular arrhythmia, with interleukin-6 (IL-6) being recognized as a crucial orchestrator of inflammatory states. Our group previously reported that levels of IL-6 were increased in the hearts of epileptic rats. In this scenario, anti-inflammatory actions are among the beneficial effects of fish oil dietary supplementation. This investigation revealed that elevated levels of IL-6 in the heart were markedly reduced in epileptic rats that were treated in the long-term with fish oil, suggesting protective anti-inflammatory actions against dangerously high levels of IL-6. Based on these findings, our results suggest beneficial effects of long-term intake of fish oil in reducing the inflammation associated with chronic epilepsy.
dc.description.issuenumberJUN
dc.description.volume8
dc.identifier.doi10.3389/fneur.2017.00263
dc.identifier.issn1664-2295
dc.identifier.urihttps://dspace.mackenzie.br/handle/10899/35758
dc.relation.ispartofFrontiers in Neurology
dc.rightsAcesso Aberto
dc.subject.otherlanguageEpilepsy
dc.subject.otherlanguageFish oil
dc.subject.otherlanguageHeart
dc.subject.otherlanguageInflammation
dc.subject.otherlanguageInterleukin-6
dc.subject.otherlanguageSudden unexpected death in epilepsy
dc.titleFish oil supplementation reduces heart levels of interleukin-6 in rats with chronic inflammation due to epilepsy
dc.typeArtigo
local.scopus.citations5
local.scopus.eid2-s2.0-85020736914
local.scopus.updated2024-05-01
local.scopus.urlhttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85020736914&origin=inward
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