Fish oil supplementation reduces heart levels of interleukin-6 in rats with chronic inflammation due to epilepsy
Tipo
Artigo
Data de publicação
2017
Periódico
Frontiers in Neurology
Citações (Scopus)
5
Autores
Nejm M.B.
Haidar A.A.
Hirata A.E.
Oyama L.M.
de Almeida A.G.
Cysneiros R.M.
Cavalheiro E.A.
Scorza C.A.
Scorza F.A.
Haidar A.A.
Hirata A.E.
Oyama L.M.
de Almeida A.G.
Cysneiros R.M.
Cavalheiro E.A.
Scorza C.A.
Scorza F.A.
Orientador
Título da Revista
ISSN da Revista
Título de Volume
Membros da banca
Programa
Resumo
© 2017 Nejm, Haidar, Hirata, Oyama, de Almeida, Cysneiros, Cavalheiro, Scorza and Scorza.Sudden unexpected death in epilepsy (SUDEP) is a major cause of premature death related to epilepsy. The causes of SUDEP remain unknown, but cardiac arrhythmias and asphyxia have been suggested as a major mechanism of this event. Inflammation has been implicated in the pathogenesis of both epilepsy and ventricular arrhythmia, with interleukin-6 (IL-6) being recognized as a crucial orchestrator of inflammatory states. Our group previously reported that levels of IL-6 were increased in the hearts of epileptic rats. In this scenario, anti-inflammatory actions are among the beneficial effects of fish oil dietary supplementation. This investigation revealed that elevated levels of IL-6 in the heart were markedly reduced in epileptic rats that were treated in the long-term with fish oil, suggesting protective anti-inflammatory actions against dangerously high levels of IL-6. Based on these findings, our results suggest beneficial effects of long-term intake of fish oil in reducing the inflammation associated with chronic epilepsy.