Quantification of neomycin in rubella vaccine by off/on metal ion mediated photoluminescence from functionalized graphene quantum dots

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dc.contributor.authorPinto I.A.
dc.contributor.authorToloza C.A.T.
dc.contributor.authorAlmeida J.M.S.
dc.contributor.authorda Silva A.R.
dc.contributor.authorLarrude D.G.
dc.contributor.authorAucelio R.Q.
dc.date.accessioned2024-03-12T23:51:54Z
dc.date.available2024-03-12T23:51:54Z
dc.date.issued2019
dc.description.abstract© 2019 Elsevier B.V.The determination of neomycin sulfate was made using photoluminescent amino-functionalized graphene quantum dots (obtained from hydro-exfoliation of a mixture of citric acid and glutathione). From the several ions tested, Fe3+ was the best mediator to enable an off/on photoluminescence effect used for quantification. The mediation of Fe3+ was found to be crucial as it is responsible for the photoluminescence quenching effect, due to the interaction with quantum dots surface, also having large affinity towards neomycin that removes Fe3+ from the surface of GQDs, consequently, promoting restoration of the original nanomaterial photoluminescence. Such signal restoration was proportional to the neomycin sulfate concentration added. The linearized analytical response covered three orders of magnitude (10−7 to 10−5 mol L−1). The proposed method is an alternative to those requiring labor-intensive procedures for chemical the derivatization of neomycin (due to the lack of chromophore groups in aminoglycosides). The method was successfully tested in the analysis of rubella vaccine containing trace residues of neomycin and in pharmaceutical compositions containing neomycin sulfate after solid phase extraction using an aminoglycoside imprinted polymer to improve selectivity in determinations.
dc.description.volume220
dc.identifier.doi10.1016/j.saa.2019.117139
dc.identifier.issn1386-1425
dc.identifier.urihttps://dspace.mackenzie.br/handle/10899/35200
dc.relation.ispartofSpectrochimica Acta - Part A: Molecular and Biomolecular Spectroscopy
dc.rightsAcesso Restrito
dc.subject.otherlanguageFe3+ mediation
dc.subject.otherlanguageFunctionalized graphene quantum dots
dc.subject.otherlanguageNeomycin sulfate
dc.subject.otherlanguagePhotoluminescence
dc.subject.otherlanguageRubella vaccine
dc.titleQuantification of neomycin in rubella vaccine by off/on metal ion mediated photoluminescence from functionalized graphene quantum dots
dc.typeArtigo
local.scopus.citations6
local.scopus.eid2-s2.0-85066130920
local.scopus.subjectFunctionalized graphene
local.scopus.subjectImprinted polymers
local.scopus.subjectNeomycin sulfates
local.scopus.subjectPhotoluminescence quenching
local.scopus.subjectRubella vaccines
local.scopus.subjectSignal restoration
local.scopus.subjectSolid-phase extraction
local.scopus.subjectThree orders of magnitude
local.scopus.subjectAminoglycosides
local.scopus.subjectGlutathione
local.scopus.subjectGraphite
local.scopus.subjectIron
local.scopus.subjectLimit of Detection
local.scopus.subjectLuminescent Measurements
local.scopus.subjectMicroscopy, Electron, Scanning Transmission
local.scopus.subjectMolecular Imprinting
local.scopus.subjectMolecular Probes
local.scopus.subjectNeomycin
local.scopus.subjectPhotoelectron Spectroscopy
local.scopus.subjectQuantum Dots
local.scopus.subjectRubella Vaccine
local.scopus.subjectSolid Phase Extraction
local.scopus.subjectSpectrum Analysis, Raman
local.scopus.subjectTemperature
local.scopus.updated2024-05-01
local.scopus.urlhttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85066130920&origin=inward
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