Association of Ang-(1–7) and des-Arg9BK as new biomarkers of obesity and cardiometabolic risk factors in adolescents

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dc.contributor.authorFernandes F.B.
dc.contributor.authorFernandes A.B.
dc.contributor.authorFebba A.C.S.
dc.contributor.authorLeite A.P.O.
dc.contributor.authorLeite C.A.
dc.contributor.authorVitalle M.S.S.
dc.contributor.authorJung F.F.
dc.contributor.authorCasarini D.E.
dc.date.accessioned2024-03-12T19:19:45Z
dc.date.available2024-03-12T19:19:45Z
dc.date.issued2021
dc.description.abstract© 2021, The Author(s), under exclusive licence to The Japanese Society of Hypertension.Children with obesity have a high risk of developing cardiovascular disease and hypertension, which is associated with the renin–angiotensin system (RAS) activation and kallikrein–kinin system (KKS) inactivation. Although recent studies have identified several peptide-based biomarkers for obesity, circulating peptides from the RAS and KKS in adolescents with obesity have not been described. The aim of this study was to examine circulating levels of RAS and KKS peptides in adolescents with obesity to investigate the turnover of these peptides and their relationship to metabolic disorders resulting from weight gain. The subjects (n = 104) were divided into normal weight (NW), overweight (OW), obese (OB), and morbidly obese (MO) groups. Anthropometric profiles were created by measuring height, weight, blood pressure, and skinfolds. Plasma levels of Ang I, II, (1–7), BK, and des-Arg9BK were quantified by high-performance liquid chromatography. The levels were as follows: Ang-(1–7)—MO 58.3 ± 50, OB 223.2 ± 150, OW 318.6 ± 190, NW 479.1 ± 160 pmol/mL, and Bradykinin (BK)—MO 367.6 ± 103, OB 253.8 ± 130, OW 484 ± 279, NW 874.9 ± 385 pmol/mL. Ang-(1–7) correlated inversely with weight, body mass index, leptin, diastolic blood pressure, and systolic blood pressure. BK and Ang-(1–7) levels correlated inversely with skinfolds, waist-hip ratio (WHR), leptin, and arm circumference. BK levels correlated with adiponectin and Ang-(1–7) levels. Plasma Ang I levels were higher in the MO and OB groups than in the NW group, but plasma Ang II levels were similar in all groups. We suggest that Ang-(1–7) and des-Arg9BK metabolites are novel biomarkers of childhood obesity that are important for determining treatment strategies.
dc.description.firstpage969
dc.description.issuenumber8
dc.description.lastpage977
dc.description.volume44
dc.identifier.doi10.1038/s41440-021-00618-0
dc.identifier.issn1348-4214
dc.identifier.urihttps://dspace.mackenzie.br/handle/10899/34619
dc.relation.ispartofHypertension Research
dc.rightsAcesso Restrito
dc.subject.otherlanguageAngiotensin (1–7)
dc.subject.otherlanguageChildhood
dc.subject.otherlanguageKallikrein–kinin system
dc.subject.otherlanguageObesity
dc.subject.otherlanguageRenin–angiotensin system
dc.titleAssociation of Ang-(1–7) and des-Arg9BK as new biomarkers of obesity and cardiometabolic risk factors in adolescents
dc.typeArtigo
local.scopus.citations12
local.scopus.eid2-s2.0-85100966299
local.scopus.subjectAdolescent
local.scopus.subjectBiomarkers
local.scopus.subjectBradykinin
local.scopus.subjectCardiometabolic Risk Factors
local.scopus.subjectChild
local.scopus.subjectHumans
local.scopus.subjectObesity, Morbid
local.scopus.subjectPediatric Obesity
local.scopus.updated2024-12-01
local.scopus.urlhttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85100966299&origin=inward
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