Impaired executive functions in experimental model of temporal lobe epilepsy Prejuízo das funções executivas no modelo experimental de epilepsia do lobo temporal

Página do item simplificado
dc.contributor.authorRamos F.O.
dc.contributor.authorCarreiro L.R.R.
dc.contributor.authorScorza F.A.
dc.contributor.authorCysneiros R.M.
dc.date.accessioned2024-03-13T00:53:05Z
dc.date.available2024-03-13T00:53:05Z
dc.date.issued2016
dc.description.abstract© 2016, Associacao Arquivos de Neuro-Psiquiatria. All Rights Reserved.Objective: The present study aimed to investigate cognitive and behavioural changes consistent with attention deficit hyperactivity disorder(ADHD-like behavior in male Wistar rats with temporal lobe epilepsy (TLE). Method: Male Wistar rats at 25 day of age were submitted toanimal model of TLE by pilocarpine injection (350 mg/kg, ip) and a control group received saline 0.9%. The animals were continuously videomonitored up to the end of experiments. The behavioural tests (open field, elevated plus maze and operant conditioning box) started from60 days postnatal. Results: Animals with TLE exhibited elevated locomotor activity, reduced level of anxiety-related behavior, impulsivityand impaired visuospatial working memory. Conclusion: Taken as a whole, we concluded that animals with TLE exhibited some cognitiveand behavioural changes consistent with ADHD-like behavior.
dc.description.firstpage470
dc.description.issuenumber6
dc.description.lastpage477
dc.description.volume74
dc.identifier.doi10.1590/0004-282X20160070
dc.identifier.issn1678-4227
dc.identifier.urihttps://dspace.mackenzie.br/handle/10899/35966
dc.relation.ispartofArquivos de Neuro-Psiquiatria
dc.rightsAcesso Aberto
dc.subject.otherlanguageEpilepsy
dc.subject.otherlanguageExecutive function
dc.subject.otherlanguageMemory
dc.subject.otherlanguagePilocarpine
dc.subject.otherlanguageShort-term
dc.subject.otherlanguageTemporal lobe
dc.titleImpaired executive functions in experimental model of temporal lobe epilepsy Prejuízo das funções executivas no modelo experimental de epilepsia do lobo temporal
dc.typeArtigo
local.scopus.citations10
local.scopus.eid2-s2.0-84975077473
local.scopus.subjectAnimals
local.scopus.subjectAttention Deficit Disorder with Hyperactivity
local.scopus.subjectDisease Models, Animal
local.scopus.subjectEpilepsy, Temporal Lobe
local.scopus.subjectExecutive Function
local.scopus.subjectExploratory Behavior
local.scopus.subjectFunctional Laterality
local.scopus.subjectMale
local.scopus.subjectMaze Learning
local.scopus.subjectRats
local.scopus.subjectRats, Wistar
local.scopus.subjectReaction Time
local.scopus.updated2024-05-01
local.scopus.urlhttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84975077473&origin=inward
Arquivos
Coleções
Artigos de periódico