Impaired executive functions in experimental model of temporal lobe epilepsy Prejuízo das funções executivas no modelo experimental de epilepsia do lobo temporal
Tipo
Artigo
Data de publicação
2016
Periódico
Arquivos de Neuro-Psiquiatria
Citações (Scopus)
10
Autores
Ramos F.O.
Carreiro L.R.R.
Scorza F.A.
Cysneiros R.M.
Carreiro L.R.R.
Scorza F.A.
Cysneiros R.M.
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Resumo
© 2016, Associacao Arquivos de Neuro-Psiquiatria. All Rights Reserved.Objective: The present study aimed to investigate cognitive and behavioural changes consistent with attention deficit hyperactivity disorder(ADHD-like behavior in male Wistar rats with temporal lobe epilepsy (TLE). Method: Male Wistar rats at 25 day of age were submitted toanimal model of TLE by pilocarpine injection (350 mg/kg, ip) and a control group received saline 0.9%. The animals were continuously videomonitored up to the end of experiments. The behavioural tests (open field, elevated plus maze and operant conditioning box) started from60 days postnatal. Results: Animals with TLE exhibited elevated locomotor activity, reduced level of anxiety-related behavior, impulsivityand impaired visuospatial working memory. Conclusion: Taken as a whole, we concluded that animals with TLE exhibited some cognitiveand behavioural changes consistent with ADHD-like behavior.
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Assuntos Scopus
Animals , Attention Deficit Disorder with Hyperactivity , Disease Models, Animal , Epilepsy, Temporal Lobe , Executive Function , Exploratory Behavior , Functional Laterality , Male , Maze Learning , Rats , Rats, Wistar , Reaction Time