KPC-producing Enterobacter aerogenes infection

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dc.contributor.authorTuon F.F.
dc.contributor.authorScharf C.
dc.contributor.authorRocha J.L.
dc.contributor.authorCieslinsk J.
dc.contributor.authorBecker G.N.
dc.contributor.authorArend L.N.
dc.date.accessioned2024-03-13T00:57:14Z
dc.date.available2024-03-13T00:57:14Z
dc.date.issued2015
dc.description.abstract© 2015 Elsevier Editora Ltda.Background: Enterobacter is a common nosocomial microorganism and its carbapenem's resistance has increased. The management of these cases is unclear. Objective: We evaluated 16 patients with KPC-producing Enterobacter aerogenes infections, detailing the site of infection, therapy, clinical and epidemiological data. Methods: A retrospective and descriptive study. Clinical data were revised and KPC-2 detection was by molecular methods. Risk factors associated with mortality were compared using appropriate tests according to variable type with a significance level of 0.05. Results: The 30-day mortality rate was 37.5% with no association with inadequate treatment. Age ( p= 0.004) and Charlson score of comorbidities ( p= 0.048) were independent risk factors associated with death in the multivariate analysis. The odds ratio for age >43 years was 3.00 (95% CI: 1.02-9.32) and for Charlson score >3 was 2.00 (95% CI: 1.08-3.71). Five strains were pan-resistant based on automated susceptibility tests. All patients were treated with monotherapy. Conclusion: The clinician should be alert to carbapenem-resistant Enterobacteriaceae infection in older patients with comorbidities. The mortality is high and we believe that prompt and adequate therapy must be employed.
dc.description.firstpage324
dc.description.issuenumber3
dc.description.lastpage327
dc.description.volume19
dc.identifier.doi10.1016/j.bjid.2015.01.003
dc.identifier.issn1678-4391
dc.identifier.urihttps://dspace.mackenzie.br/handle/10899/36200
dc.relation.ispartofBrazilian Journal of Infectious Diseases
dc.rightsAcesso Aberto
dc.subject.otherlanguageCarbapenemase
dc.subject.otherlanguageEnterobacter
dc.subject.otherlanguageInfection control
dc.subject.otherlanguageKPC
dc.titleKPC-producing Enterobacter aerogenes infection
dc.typeArtigo
local.scopus.citations14
local.scopus.eid2-s2.0-84930089014
local.scopus.subjectAdult
local.scopus.subjectAged
local.scopus.subjectAged, 80 and over
local.scopus.subjectAnti-Bacterial Agents
local.scopus.subjectbeta-Lactamases
local.scopus.subjectEnterobacter aerogenes
local.scopus.subjectEnterobacteriaceae Infections
local.scopus.subjectFemale
local.scopus.subjectHumans
local.scopus.subjectMale
local.scopus.subjectMicrobial Sensitivity Tests
local.scopus.subjectMiddle Aged
local.scopus.subjectPregnancy
local.scopus.subjectRetrospective Studies
local.scopus.subjectRisk Factors
local.scopus.subjectYoung Adult
local.scopus.updated2024-05-01
local.scopus.urlhttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84930089014&origin=inward
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