KPC-producing Enterobacter aerogenes infection

Data de publicação
Brazilian Journal of Infectious Diseases
Citações (Scopus)
Tuon F.F.
Scharf C.
Rocha J.L.
Cieslinsk J.
Becker G.N.
Arend L.N.
Título da Revista
ISSN da Revista
Título de Volume
Membros da banca
© 2015 Elsevier Editora Ltda.Background: Enterobacter is a common nosocomial microorganism and its carbapenem's resistance has increased. The management of these cases is unclear. Objective: We evaluated 16 patients with KPC-producing Enterobacter aerogenes infections, detailing the site of infection, therapy, clinical and epidemiological data. Methods: A retrospective and descriptive study. Clinical data were revised and KPC-2 detection was by molecular methods. Risk factors associated with mortality were compared using appropriate tests according to variable type with a significance level of 0.05. Results: The 30-day mortality rate was 37.5% with no association with inadequate treatment. Age ( p= 0.004) and Charlson score of comorbidities ( p= 0.048) were independent risk factors associated with death in the multivariate analysis. The odds ratio for age >43 years was 3.00 (95% CI: 1.02-9.32) and for Charlson score >3 was 2.00 (95% CI: 1.08-3.71). Five strains were pan-resistant based on automated susceptibility tests. All patients were treated with monotherapy. Conclusion: The clinician should be alert to carbapenem-resistant Enterobacteriaceae infection in older patients with comorbidities. The mortality is high and we believe that prompt and adequate therapy must be employed.
Assuntos Scopus
Adult , Aged , Aged, 80 and over , Anti-Bacterial Agents , beta-Lactamases , Enterobacter aerogenes , Enterobacteriaceae Infections , Female , Humans , Male , Microbial Sensitivity Tests , Middle Aged , Pregnancy , Retrospective Studies , Risk Factors , Young Adult
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