Perfil anatomopatológico e imunohistoquímico dos gliomas operados em um hospital quaternário da região metropolitana de Curitiba. Análise de sete anos.
Tipo
TCC
Data de publicação
2025-05-29
Periódico
Citações (Scopus)
Autores
Barghouthi, Guilherme Costa
Carreiro, João Vittor Oliveira
Carreiro, João Vittor Oliveira
Orientador
Buffon, Viviane Aline
Título da Revista
ISSN da Revista
Título de Volume
Membros da banca
Programa
Resumo
Introdução: Gliomas são tumores cerebrais primários com alta morbimortalidade, cuja classificação molecular, baseada em marcadores como IDH-1, Ki-67, p53 e ATRX, é essencial para diagnóstico e prognóstico. A epidemiologia pode variar regionalmente, exigindo estudos locais para caracterizar padrões de incidência e perfis tumorais. Objetivos: Analisar retrospectivamente os perfis anatomopatológicos e imunohistoquímicos de gliomas operados em um Hospital quaternário da região metropolitana de Curitiba, entre 2017 e 2023, comparando dados epidemiológicos e marcadores moleculares com a literatura. Métodos: Estudo transversal, retrospectivo e descritivo, baseado em 106 laudos anatomopatológicos de pacientes com gliomas atendidos no Hospital do Rocio, Campo Largo-PR, de 2017 a 2023. Foram analisados sexo, idade e marcadores imunohistoquímicos (Ki-67, p53, ATRX, IDH-1). Resultados: Dos 106 pacientes, 55,6% eram homens, com média etária geral de 53 anos. Glioblastomas (73,6%) predominaram em 50-70 anos, e outros gliomas (26,4%) em <50 anos. Ki-67 foi alto (>30%) em 73% dos glioblastomas; p53 apresentou 21 casos intermediários em glioblastomas; ATRX mostrou perda em 3/13 outros gliomas; IDH-1 foi positivo em 13/13 106 casos) sugerem a necessidade de maior acesso a exames e estudos ampliados.glioblastomas avaliados e 6/14 outros gliomas. Conclusão: Os achados confirmam predominância masculina e perfis moleculares consistentes com glioblastomas secundários com particularidades regionais. Limitações na testagem molecular (ex.: IDH-1 em 27/
Introduction: Gliomas are primary brain tumors with high morbidity and mortality, whose molecular classification—based on markers such as IDH-1, Ki-67, p53, and ATRX—is essential for diagnosis and prognosis. Epidemiological patterns vary regionally, highlighting the need for local studies to characterize incidence trends and tumor profiles. Objectives: To retrospectively analyze the anatomopathological and immunohistochemical profiles of gliomas surgically treated at a quaternary hospital in the metropolitan region of Curitiba, between 2017 and 2023, comparing epidemiological data and molecular markers with the existing literature. Methods: A cross-sectional, observational, quantitative, and retrospective study based on 106 histopathological reports of patients with gliomas treated at Hospital do Rocio, Campo Largo-PR, from 2017 to 2023. Data on sex, age, and immunohistochemical markers (Ki-67, p53, ATRX, IDH-1) were analyzed. Results: Of the 106 patients, 55.6% were male, with an overall mean age of 53 years. Glioblastomas (73.6%) predominated among patients aged 50–70, while other gliomas (26.4%) were more frequent in those under 50. Ki-67 was high (>30%) in 73% of glioblastomas; p53 showed 21 intermediate-expression cases in glioblastomas; ATRX loss was observed in 3 out of 13 non-glioblastoma gliomas; IDH-1 was positive in 13 out of 13 evaluated glioblastomas and in 6 out of 14 other gliomas. Conclusion: The findings confirm a male predominance and molecular profiles consistent with secondary glioblastomas with regional particularities. Limitations in molecular testing (e.g., IDH-1 performed in 27/106 cases) suggest the need for broader access to diagnostic tools and expanded studies.
Introduction: Gliomas are primary brain tumors with high morbidity and mortality, whose molecular classification—based on markers such as IDH-1, Ki-67, p53, and ATRX—is essential for diagnosis and prognosis. Epidemiological patterns vary regionally, highlighting the need for local studies to characterize incidence trends and tumor profiles. Objectives: To retrospectively analyze the anatomopathological and immunohistochemical profiles of gliomas surgically treated at a quaternary hospital in the metropolitan region of Curitiba, between 2017 and 2023, comparing epidemiological data and molecular markers with the existing literature. Methods: A cross-sectional, observational, quantitative, and retrospective study based on 106 histopathological reports of patients with gliomas treated at Hospital do Rocio, Campo Largo-PR, from 2017 to 2023. Data on sex, age, and immunohistochemical markers (Ki-67, p53, ATRX, IDH-1) were analyzed. Results: Of the 106 patients, 55.6% were male, with an overall mean age of 53 years. Glioblastomas (73.6%) predominated among patients aged 50–70, while other gliomas (26.4%) were more frequent in those under 50. Ki-67 was high (>30%) in 73% of glioblastomas; p53 showed 21 intermediate-expression cases in glioblastomas; ATRX loss was observed in 3 out of 13 non-glioblastoma gliomas; IDH-1 was positive in 13 out of 13 evaluated glioblastomas and in 6 out of 14 other gliomas. Conclusion: The findings confirm a male predominance and molecular profiles consistent with secondary glioblastomas with regional particularities. Limitations in molecular testing (e.g., IDH-1 performed in 27/106 cases) suggest the need for broader access to diagnostic tools and expanded studies.
Descrição
Palavras-chave
gliomas , glioblastoma , imunohistoquímica , epidemiologia , neuropatologia , immunohistochemistry , epidemiology , neuropathology , gliomas , glioblastoma