Alterações comportamentais e cognitivas em ratos expostos às crises epilépticas intrauterinas

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dc.contributor.advisorCysneiros, Roberta Monterazzopt_BR
dc.contributor.advisor1Latteshttp://lattes.cnpq.br/9822955080635086por
dc.contributor.authorNovaes, Gisane Fariapt_BR
dc.creator.Latteshttp://lattes.cnpq.br/5223200091427272por
dc.date.accessioned2016-03-15T19:39:38Z
dc.date.accessioned2020-03-19T15:19:50Z
dc.date.available2011-02-03pt_BR
dc.date.available2020-03-19T15:19:50Z
dc.date.issued2010-08-05pt_BR
dc.description.abstractIt is well established that exposure to teratogenic agents, like valproic acid, increase the risk of developing autism spectrum disorders. Considering that epileptic pregnant woman use antiepileptic therapy, it makes difficult to search evidences whether the epilepsy per se, when uncontrolled, produce alterations on offspring or whether the medication associated with the genetic predisposition are the factor responsible for these alterations. Animal models are useful once variables can be controlled. This study evaluated the behavior of offspring exposed to maternal convulsive seizures in utero. An experimental model of temporal lobe epilepsy was induced in female wistar by pilocarpine administration (350 mg/kg). Control animals received saline injection. After the occurrence of spontaneous seizure, the rats were mated and seizure frequency was recorded (6h/day) during the pregnancy. Early after birth, rat pups from epileptic and control dams were cross-fostered with a control dams. The third group pups born from control dams were maintained with their own mother. Number of pups per litter from epileptic dams was significantly reduced, and malformations were present in 15% of them. The animal behaviors were analyzed from postnatal days 60. Offspring from epileptic dam showed deficit in social interaction and cognition, with no changes in anxiety, suggesting that epileptic seizures during pregnancy is harmful to fetal developing. Furthers studies are need for a broader assessment of animal behavior repertoire across the life span, independently the seizures during pregnancy to be or not a risk factor for developing of autism spectrum disorder.eng
dc.description.sponsorshipFundo Mackenzie de Pesquisapt_BR
dc.formatapplication/pdfpor
dc.identifier.urihttp://dspace.mackenzie.br/handle/10899/22464
dc.languageporpor
dc.publisherUniversidade Presbiteriana Mackenziepor
dc.rightsAcesso Abertopor
dc.subjectepilepsiapor
dc.subjectgestaçãopor
dc.subjectinteração socialpor
dc.subjectansiedadepor
dc.subjectcogniçãopor
dc.subjectepilepsyeng
dc.subjectpregnancyeng
dc.subjectsocial interactioneng
dc.subjectanxietyeng
dc.subjectcognitioneng
dc.subject.cnpqCNPQ::CIENCIAS HUMANASpor
dc.thumbnail.urlhttp://tede.mackenzie.br/jspui/retrieve/3664/Gisane%20Faria%20Novaes.pdf.jpg*
dc.titleAlterações comportamentais e cognitivas em ratos expostos às crises epilépticas intrauterinaspor
dc.typeDissertaçãopor
local.contributor.board1Schwartzman, José Salomãopt_BR
local.contributor.board1Latteshttp://lattes.cnpq.br/1470693655000888por
local.contributor.board2Scorza, Fúlvio Alexandrept_BR
local.contributor.board2Latteshttp://lattes.cnpq.br/3665794780601169por
local.publisher.countryBRpor
local.publisher.departmentPsicologiapor
local.publisher.initialsUPMpor
local.publisher.programDistúrbios do Desenvolvimentopor
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Distúrbios do Desenvolvimento - Dissertações - CCBS Higienópolis