Correlation of the Neutrophil-To-lymphocyte and Platelet-To-lymphocyte Ratios with Postoperative Complications and Survival in Surgery for Bone Metastasis of the Appendicular Skeleton Correlação das razões neutrófilo-linfócito e plaqueta-linfócito com complicações e sobrevida pós-operatórias na cirurgia para metástase óssea do esqueleto apendicular
Tipo
Artigo
Data de publicação
2025
Periódico
Revista Brasileira de Ortopedia
Citações (Scopus)
0
Autores
Teixeira M.S.
Teixeira A.V.R.
Mello G.J.P.
Tabushi F.I.
Franck C.L.
Ribas C.A.P.M.
Teixeira A.V.R.
Mello G.J.P.
Tabushi F.I.
Franck C.L.
Ribas C.A.P.M.
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Resumo
© 2025. The Author(s).Objective To analyze, in cases of long-bone metastases, the incidence of postoperative complications and survival of up to 1 year, correlating themwith the neutrophil-Tolymphocyte ratio (NLR) and platelet-To-lymphocyte ratio (PLR). Methods Review of 160 medical records of patients who underwent surgery for bone metastases in the appendicular skeleton. We determined epidemiological characteristics and NLR and PLR values, which were correlated with survival and complications. Results Women represented 64.5% of the sample, and 62.6% presented primary breast tumor. The proximal femur was themost affected bone. Themedian survival was of 13.2 months, and the 1-year survival rate, of 34.7%. Tumor resection with endoprosthesis was themost common surgery. The postoperative complication rate was of 10%, and the mean time until occurrence was of 27.9 (range: 0 140) days. We observed a significant association between neutrophil levels and postoperative complications (p 0.04): for every increase of 100 neutrophils, the risk of postoperative complications increased by 1%. The mean NLR and PLR values were of 5.3 (range: 0.2 30.7) and 199.7 (range: 32.1 676.7) respectively. Patients with NLR 2 (p<0,001) showed a decrease in survival from 92,3 to 62,5% in the third month, and from 61,5 to 31,3% in the first year. Those with PLR 209 (p<0.001) showed a decrease in survival from 69 to 59.3% in the third month, and from 40.2 to 25.9% in the first year. Conclusion There was no positive association regarding the NLR and PLR and postoperative complications. However, we noted a strong correlation involving elevated NLR and PLR levels and reduced life expectancy starting from the third postoperative month.