Chromenes from Peperomia serpens (Sw.) Loudon (Piperaceae)

Saga Kitamura R.O.; Romoff P.; Young M.C.M.; Kato M.J.; Lago J.H.G.

Chromenes from Peperomia serpens (Sw.) Loudon (Piperaceae)

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Artigo

Date

2006

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Phytochemistry

item.page.citationsscopus

77

Authors

Saga Kitamura R.O.
Romoff P.
Young M.C.M.
Kato M.J.
Lago J.H.G.

Abstract

Chromatographic separation of the CH2Cl2 extract from leaves of Peperomia serpens yielded two chromenes [5-hydroxy-8-(3′,7′-dimethylocta-2′,6′-dienyl)-2,2,7-trimethyl-2H-1-chromene (1) and 5-hydroxy-8-(3′-methyl-2′-butenyl)-2,2,7-trimethyl-2H-1-chromene-6-carboxylic acid (2)], besides the known chromene [methyl 5-hydroxy-2,2,7-trimethyl-2H-1-chromene-6-carboxylate (3)] and the flavonoid, dihydrooroxylin (4). Their structural elucidation were achieved by spectroscopic analyses. The antifungal activities of the CH2Cl2 extract and the isolated chromenes were measured bioautographically against Cladosporium cladosporioides and C. sphaerospermum, when it was found that the crude extract showed higher activity as compared to the pure compounds. © 2006 Elsevier Ltd. All rights reserved.