Caldensinic acid, a prenylated benzoic acid from Piper caldense
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Artigo
Date
2009
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Phytochemistry Letters
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11
Authors
Freitas G.C.
Kitamura R.O.S.
Lago J.H.G.
Young M.C.M.
Guimaraes E.F.
Kato M.J.
Kitamura R.O.S.
Lago J.H.G.
Young M.C.M.
Guimaraes E.F.
Kato M.J.
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Abstract
The CH2Cl2 and MeOH extracts from leaves of Piper caldense were subjected to chromatographic separation procedures to afford the new prenylated benzoic acid, caldensinic acid (3-[(2′E,6′E,10′E)-11′-carboxy-3′,7′,15′-trimethylhexadeca-2′,6′,10′,14′-tetraenyl]-4,5-dihydroxybenzoic acid) whose structure was determined by spectral analysis, mainly NMR (1H, 13C, HSQC, HMBC) and ESI-MS. The natural compound and derivatives displayed antifungal activity against the phytopathogenic fungi Cladosporium cladosporioides and C. sphaerospermum by direct bioautography. © 2009 Phytochemical Society of Europe.