Long-term obesity is associated with depression and neuroinflammation

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dc.contributor.authorLorena F.B.
dc.contributor.authorDo Nascimento B.P.P.
dc.contributor.authorCamargo E.L.R.A.
dc.contributor.authorBernardi M.M.
dc.contributor.authorFukushima A.R.
dc.contributor.authorPanizza J.D.N.
dc.contributor.authorNogueira P.B.
dc.contributor.authorBrandao M.E.S.
dc.contributor.authorRibeiro M.O.
dc.date.accessioned2024-03-12T19:22:26Z
dc.date.available2024-03-12T19:22:26Z
dc.date.issued2021
dc.description.abstract© AE&Mall rights reserved.Objective: Obesity is characterized by a state of chronic, low-intensity systemic inflammation frequently associated with insulin resistance and dyslipidemia. Materials and methods: Given that chronic inflammation has been implicated in the pathogenesis of mood disorders, we investigated if chronic obesity that was initiated early in life – lasting through adulthood – could be more harmful to memory impairment and mood fluctuations such as depression. Results: Here we show that pre-pubertal male rats (30 days old) treated with a high-fat diet (40%) for 8-months gained ~50% more weight when compared to controls, exhibited depression and anxiety-like behaviors but no memory impairment. The prefrontal cortex of the obese rats exhibited an increase in the expression of genes related to inflammatory response, such as NFKb, MMP9, CCl2, PPARb, and PPARg. There were no alterations in genes known to be related to depression. Conclusion: Long-lasting obesity with onset in prepuberal age led to depression and neuroinflammation but not to memory impairment. Arch Endocrinol Metab. 2021;65(5):537-48.
dc.description.firstpage537
dc.description.issuenumber5
dc.description.lastpage548
dc.description.volume65
dc.identifier.doi10.20945/2359-3997000000400
dc.identifier.issn2359-4292
dc.identifier.urihttps://dspace.mackenzie.br/handle/10899/34766
dc.relation.ispartofArchives of Endocrinology and Metabolism
dc.rightsAcesso Aberto
dc.subject.otherlanguageBehavior
dc.subject.otherlanguageCognition
dc.subject.otherlanguageDepression
dc.subject.otherlanguageJuvenile obesity
dc.subject.otherlanguageNeuroinflammation
dc.titleLong-term obesity is associated with depression and neuroinflammation
dc.typeArtigo
local.scopus.citations10
local.scopus.eid2-s2.0-85121051530
local.scopus.subjectAnimals
local.scopus.subjectAnxiety
local.scopus.subjectBehavior, Animal
local.scopus.subjectDepression
local.scopus.subjectDiet, High-Fat
local.scopus.subjectMale
local.scopus.subjectObesity
local.scopus.subjectRats
local.scopus.updated2024-11-01
local.scopus.urlhttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85121051530&origin=inward
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