Prefrontal cortex modulation using transcranial DC stimulation reduces alcohol craving: A double-blind, sham-controlled study

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dc.contributor.authorBoggio P.S.
dc.contributor.authorSultani N.
dc.contributor.authorFecteau S.
dc.contributor.authorMerabet L.
dc.contributor.authorMecca T.
dc.contributor.authorPascual-Leone A.
dc.contributor.authorBasaglia A.
dc.contributor.authorFregni F.
dc.date.accessioned2024-03-13T01:38:52Z
dc.date.available2024-03-13T01:38:52Z
dc.date.issued2008
dc.description.abstractBackground: Functional neuroimaging studies have shown that specific brain areas are associated with alcohol craving including the dorsolateral prefrontal cortex (DLPFC). We tested whether modulation of DLPFC using transcranial direct current stimulation (tDCS) could alter alcohol craving in patients with alcohol dependence while being exposed to alcohol cues. Methods: We performed a randomized sham-controlled study in which 13 subjects received sham and active bilateral tDCS delivered to DLPFC (anodal left/cathodal right and anodal right/cathodal left). For sham stimulation, the electrodes were placed at the same positions as in active stimulation; however, the stimulator was turned off after 30 s of stimulation. Subjects were presented videos depicting alcohol consumption to increase alcohol craving. Results: Our results showed that both anodal left/cathodal right and anodal right/cathodal left significantly decreased alcohol craving compared to sham stimulation (p < 0.0001). In addition, we found that following treatment, craving could not be further increased by alcohol cues. Conclusions: Our findings showed that tDCS treatment to DLPFC can reduce alcohol craving. These findings extend the results of previous studies using noninvasive brain stimulation to reduce craving in humans. Given the relatively rapid suppressive effect of tDCS and the highly fluctuating nature of alcohol craving, this technique may prove to be a valuable treatment strategy within the clinical setting. © 2007 Elsevier Ireland Ltd. All rights reserved.
dc.description.firstpage55
dc.description.issuenumber1-3
dc.description.lastpage60
dc.description.volume92
dc.identifier.doi10.1016/j.drugalcdep.2007.06.011
dc.identifier.issn0376-8716
dc.identifier.urihttps://dspace.mackenzie.br/handle/10899/37593
dc.relation.ispartofDrug and Alcohol Dependence
dc.rightsAcesso Restrito
dc.subject.otherlanguageAlcohol craving
dc.subject.otherlanguageBrain stimulation
dc.subject.otherlanguageDorsolateral prefrontal cortex
dc.subject.otherlanguageTranscranial direct current stimulation
dc.titlePrefrontal cortex modulation using transcranial DC stimulation reduces alcohol craving: A double-blind, sham-controlled study
dc.typeArtigo
local.scopus.citations284
local.scopus.eid2-s2.0-36849094536
local.scopus.updated2024-05-01
local.scopus.urlhttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=36849094536&origin=inward
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