High serum levels of proinflammatory markers during epileptogenesis. Can omega-3 fatty acid administration reduce this process?

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dc.contributor.authorGouveia T.L.F.
dc.contributor.authorVieira de Sousa P.V.
dc.contributor.authorde Almeida S.S.
dc.contributor.authorNejm M.B.
dc.contributor.authorVieira de Brito J.M.
dc.contributor.authorCysneiros R.M.
dc.contributor.authorde Brito M.V.
dc.contributor.authorSalu B.R.
dc.contributor.authorOliva M.L.V.
dc.contributor.authorScorza F.A.
dc.contributor.authorNaffah-Mazzacoratti M.D.G.
dc.date.accessioned2024-03-13T00:56:17Z
dc.date.available2024-03-13T00:56:17Z
dc.date.issued2015
dc.description.abstract© 2015 Elsevier Inc.During the epileptogenic process, several events may occur, such as an important activation of the immune system in the central nervous system. The response to seizure activity results in an inflammation in the brain as well as in the periphery. Moreover, CRP and cytokines may be able to interact with numerous ligands in response to cardiac injury caused by sympathetic stimulation in ictal and postictal states. Based on this, we measured the serum levels of C-reactive protein (CRP) and cytokines during acute, silent, and chronic phases of rats submitted to the pilocarpine model of epilepsy. We have also analyzed the effect of a chronic treatment of these rats with omega-3 fatty acid in CRP and cytokine levels, during an epileptic focus generation. C-reactive protein and cytokines such as IL-1β, IL-6, and TNF-α presented high concentration in the blood of rats, even well after the occurrence of SE. We found reduced levels of CRP and all proinflammatory cytokines in the blood of animals with chronic seizures, treated with omega-3, when compared with those treated with vehicle solution. Taken together, our results strongly suggest that the omega-3 is an effective treatment to prevent SUDEP occurrence due to its capability to act as an anti-inflammatory compound, reducing the systemic inflammatory parameters altered by seizures.
dc.description.firstpage300
dc.description.lastpage305
dc.description.volume51
dc.identifier.doi10.1016/j.yebeh.2015.07.021
dc.identifier.issn1525-5069
dc.identifier.urihttps://dspace.mackenzie.br/handle/10899/36146
dc.relation.ispartofEpilepsy and Behavior
dc.rightsAcesso Aberto
dc.subject.otherlanguageC-reactive protein
dc.subject.otherlanguageCytokines
dc.subject.otherlanguageEpileptogenesis
dc.subject.otherlanguageOmega-3 fatty acid
dc.subject.otherlanguagePilocarpine
dc.subject.otherlanguageTemporal lobe epilepsy
dc.titleHigh serum levels of proinflammatory markers during epileptogenesis. Can omega-3 fatty acid administration reduce this process?
dc.typeArtigo
local.scopus.citations19
local.scopus.eid2-s2.0-84940369068
local.scopus.subjectAnimals
local.scopus.subjectBehavior, Animal
local.scopus.subjectBiomarkers
local.scopus.subjectC-Reactive Protein
local.scopus.subjectConvulsants
local.scopus.subjectCytokines
local.scopus.subjectEpilepsy
local.scopus.subjectFatty Acids, Omega-3
local.scopus.subjectInflammation
local.scopus.subjectMale
local.scopus.subjectPilocarpine
local.scopus.subjectRats
local.scopus.subjectRats, Wistar
local.scopus.subjectStatus Epilepticus
local.scopus.updated2024-05-01
local.scopus.urlhttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84940369068&origin=inward
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