Chemical composition and anti-inflammatory evaluation of essential oils from leaves and stem barks from Drimys brasiliensis Miers (Winteraceae)

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dc.contributor.authorLago J.H.G.
dc.contributor.authorCarvalho L.A.C.
dc.contributor.authorDa Silva F.S.
dc.contributor.authorToyama D.D.O.
dc.contributor.authorFavero O.A.
dc.contributor.authorRomoff P.
dc.date.accessioned2024-03-13T01:32:50Z
dc.date.available2024-03-13T01:32:50Z
dc.date.issued2010
dc.description.abstractThe essential oils from leaves and stem barks from Drimys brasiliensis Miers (Winteraceae) were individually obtained by hydrodistillation and their compounds characterized by use of GC/FID and GC/MS. The main identified derivatives were monoterpenes (leaves 4.31% and stem barks 90.02%) and sesquiterpenes (leaves 52.31% and stem barks 6.35%). Additionally, the sesquiterpene polygodial was isolated from hexane extract from stem barks of D. brasiliensis after chromatographic steps and characterized by spectroscopic means, mainly NMR. Aiming the evaluation of anti-inflammatory potential, the crude essential oils and the sesquiterpene polygodial were subjected to bioassays to evaluate the acute toxicity of these compounds as well as the anti-inflammatory and antinociceptive activities induced by carrageenan and formalin in mices. Ours results showed that essential oil obtained from the stem barks significantly reduced the oedema induced by carrageenan. The anti-inflammatory effect induced by stem barks oil (at 200 mg kg-1) was similar to observed for indomethacin (at 10 mg kg-1) and superior for polygodial (at 200 mg kg-1) in 30 and 60 min after the administration of essential oils. The inflammatory response induced by formalin was effective to the stem barks oil (62.5%) in comparison to polygodial (50.0%). - © 2010 Sociedade Brasileira de Química.
dc.description.firstpage1760
dc.description.issuenumber9
dc.description.lastpage1765
dc.description.volume21
dc.identifier.doi10.1590/S0103-50532010000900024
dc.identifier.issn1678-4790
dc.identifier.urihttps://dspace.mackenzie.br/handle/10899/37257
dc.relation.ispartofJournal of the Brazilian Chemical Society
dc.rightsAcesso Aberto
dc.subject.otherlanguageAcute toxicity
dc.subject.otherlanguageAntiinflammatory
dc.subject.otherlanguageAntinociceptive
dc.subject.otherlanguageDrimys brasiliensis miers
dc.subject.otherlanguageEssential oil composition
dc.titleChemical composition and anti-inflammatory evaluation of essential oils from leaves and stem barks from Drimys brasiliensis Miers (Winteraceae)
dc.typeArtigo
local.scopus.citations26
local.scopus.eid2-s2.0-77956434640
local.scopus.updated2024-05-01
local.scopus.urlhttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=77956434640&origin=inward
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