Effect of diazepam on sociability of rats submitted to neonatal seizures

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dc.contributor.authorLeite I.S.
dc.contributor.authorCastelhano A.S.S.
dc.contributor.authorCysneiros R.M.
dc.date.accessioned2024-03-13T00:53:07Z
dc.date.available2024-03-13T00:53:07Z
dc.date.issued2016
dc.description.abstract© 2016 The Authors.Status epilepticus (SE), an acute condition characterized by repetitive or ongoing seizures activity, may produce long-term deleterious consequences. Previous data demonstrated that Wistar rats subjected to neonatal SE displayed autistic behavior, characterized by social play impairment, low preference by novelty, deficit in social discrimination; anxiety related behavior and stereotyped behavior with no changes in locomotor activity (doi: http://dx.doi.org/10.1007/s00702-010-0460-1, doi: http://dx.doi.org/10.3389/fnbeh.2013.00036, doi: http://dx.doi.org/10.1007/s00702-014-1291-2 [1-3]). Taking into account the bi-directional relationship between the state of anxiety and social interaction (doi: http://dx.doi.org/10.1007/s10567-009-0062-3 [4]), we evaluated the impact of the state of anxiety on social interaction. Male Wistar rats at postnatal day 9 were subjected to pilocarpine-induced neonatal SE (380 mg/kg, ip) and the controls received 0.9% saline (0.1 ml/10 g). The groups received saline or diazepam (1.0 mg/kg) 45 min prior each behavioral testing that started from 60 days of postnatal life. In the open field, rats subjected to neonatal seizure exhibited less central zone activity as compared to animals treated with diazepam, with no changes in the total locomotor activity. In elevated plus maze, rats subjected to neonatal seizure and treated with diazepam exhibited higher locomotor activity and spent more time on the open arms as compared to untreated animals. In approach phase of sociability paradigm, animals subjected to neonatal seizures similarly to controls, regardless the treatment, spent more time with social stimulus as compared to non social stimulus. In social novelty phase of sociability paradigm, animals subjected to neonatal seizures differently of controls, regardless the treatment, spent similar time with familiar and novel stimulus.
dc.description.firstpage686
dc.description.lastpage691
dc.description.volume7
dc.identifier.doi10.1016/j.dib.2016.03.029
dc.identifier.issn2352-3409
dc.identifier.urihttps://dspace.mackenzie.br/handle/10899/35968
dc.relation.ispartofData in Brief
dc.rightsAcesso Aberto
dc.subject.otherlanguageAnxiety
dc.subject.otherlanguageDiazepam
dc.subject.otherlanguageNeonatal seizures
dc.subject.otherlanguagePilocarpine
dc.subject.otherlanguageSociability
dc.titleEffect of diazepam on sociability of rats submitted to neonatal seizures
dc.typeArtigo
local.scopus.citations12
local.scopus.eid2-s2.0-84960909778
local.scopus.subjectAnxiety
local.scopus.subjectCondition
local.scopus.subjectDiazepam
local.scopus.subjectLocomotor activity
local.scopus.subjectNeonatal seizure
local.scopus.subjectPilocarpine
local.scopus.subjectSociability
local.scopus.subjectSocial interactions
local.scopus.subjectStatus epilepticus
local.scopus.subjectWistar rat
local.scopus.updated2024-05-01
local.scopus.urlhttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84960909778&origin=inward
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