Transcranial direct current stimulation (tDCS) in unipolar vs. bipolar depressive disorder

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dc.contributor.authorBrunoni A.R.
dc.contributor.authorFerrucci R.
dc.contributor.authorBortolomasi M.
dc.contributor.authorVergari M.
dc.contributor.authorTadini L.
dc.contributor.authorBoggio P.S.
dc.contributor.authorGiacopuzzi M.
dc.contributor.authorBarbieri S.
dc.contributor.authorPriori A.
dc.date.accessioned2024-03-13T01:11:54Z
dc.date.available2024-03-13T01:11:54Z
dc.date.issued2011
dc.description.abstractTranscranial direct current stimulation (tDCS) is a non-invasive method for brain stimulation. Although pilot trials have shown that tDCS yields promising results for major depressive disorder (MDD), its efficacy for bipolar depressive disorder (BDD), a condition with high prevalence and poor treatment outcomes, is unknown. In a previous study we explored the effectiveness of tDCS for MDD. Here, we expanded our research, recruiting patients with MDD and BDD. We enrolled 31 hospitalized patients (24 women) aged 30-70. years 17 with MDD and 14 with BDD (n = 14). All patients received stable drug regimens for at least two weeks before enrollment and drug dosages remained unchanged throughout the study. We applied tDCS over the dorsolateral prefrontal cortex (anodal electrode on the left and cathodal on the right) using a 2. mA-current for 20. min, twice-daily, for 5 consecutive days. Depression was measured at baseline, after 5 tDCS sessions, one week later, and one month after treatment onset. We used the scales of Beck (BDI) and Hamilton-21 items (HDRS). All patients tolerated treatment well without adverse effects. After the fifth tDCS session, depressive symptoms in both study groups diminished, and the beneficial effect persisted at one week and one month. In conclusion, our preliminary study suggests that tDCS is a promising treatment for patients with MDD and BDD.2. © 2010 Elsevier Inc.
dc.description.firstpage96
dc.description.issuenumber1
dc.description.lastpage101
dc.description.volume35
dc.identifier.doi10.1016/j.pnpbp.2010.09.010
dc.identifier.issn0278-5846
dc.identifier.urihttps://dspace.mackenzie.br/handle/10899/37022
dc.relation.ispartofProgress in Neuro-Psychopharmacology and Biological Psychiatry
dc.rightsAcesso Restrito
dc.subject.otherlanguageBipolar disorder
dc.subject.otherlanguageClinical trial
dc.subject.otherlanguageMajor depressive disorder
dc.subject.otherlanguageNon-invasive brain stimulation
dc.subject.otherlanguageTranscranial direct current stimulation
dc.titleTranscranial direct current stimulation (tDCS) in unipolar vs. bipolar depressive disorder
dc.typeArtigo
local.scopus.citations166
local.scopus.eid2-s2.0-78650942224
local.scopus.updated2024-05-01
local.scopus.urlhttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=78650942224&origin=inward
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