Pseudoboehmite as a drug delivery system for acyclovir

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dc.contributor.authorPeres R.M.
dc.contributor.authorSousa J.M.L.
dc.contributor.authorde Oliveira M.O.
dc.contributor.authorRossi M.V.
dc.contributor.authorde Oliveira R.R.
dc.contributor.authorde Lima N.B.
dc.contributor.authorBernussi A.
dc.contributor.authorWarzywoda J.
dc.contributor.authorSarmento B.
dc.contributor.authorMunhoz A.H.
dc.date.accessioned2024-03-12T19:18:28Z
dc.date.available2024-03-12T19:18:28Z
dc.date.issued2021
dc.description.abstract© 2021, The Author(s).Herpes simplex virus is among the most prevalent sexually transmitted infections. Acyclovir is a potent, selective inhibitor of herpes viruses and it is indicated for the treatment and management of recurrent cold sores on the lips and face, genital herpes, among other diseases. The problem of the oral bioavailability of acyclovir is limited because of the low permeability across the gastrointestinal membrane. The use of nanoparticles of pseudoboehmite as a drug delivery system in vitro assays is a promising approach to further the permeability of acyclovir release. Here we report the synthesis of high purity pseudoboehmite from aluminium nitrate and ammonium hydroxide containing nanoparticles, using the sol–gel method, as a drug delivery system to improve the systemic bioavailability of acyclovir. The presence of pseudoboehmite nanoparticles were verified by infrared spectroscopy, transmission electron microscopy, and X-ray diffraction techniques. In vivo tests were performed with Wistar rats to compare the release of acyclovir, with and without the addition of pseudoboehmite. The administration of acyclovir with the addition of pseudoboehmite increased the drug content by 4.6 times in the plasma of Wistar rats after 4 h administration. We determined that the toxicity of pseudoboehmite is low up to 10 mg/mL, in gel and the dried pseudoboehmite nanoparticles.
dc.description.issuenumber1
dc.description.volume11
dc.identifier.doi10.1038/s41598-021-94325-y
dc.identifier.issn2045-2322
dc.identifier.urihttps://dspace.mackenzie.br/handle/10899/34552
dc.relation.ispartofScientific Reports
dc.rightsAcesso Aberto
dc.titlePseudoboehmite as a drug delivery system for acyclovir
dc.typeArtigo
local.scopus.citations7
local.scopus.eid2-s2.0-85111614766
local.scopus.subjectAcyclovir
local.scopus.subjectAdministration, Oral
local.scopus.subjectAluminum Hydroxide
local.scopus.subjectAluminum Oxide
local.scopus.subjectAnimals
local.scopus.subjectAntiviral Agents
local.scopus.subjectBiological Availability
local.scopus.subjectCaco-2 Cells
local.scopus.subjectCell Survival
local.scopus.subjectDrug Delivery Systems
local.scopus.subjectDrug Liberation
local.scopus.subjectHerpes Simplex
local.scopus.subjectHumans
local.scopus.subjectModels, Animal
local.scopus.subjectNanogels
local.scopus.subjectRats
local.scopus.subjectRats, Wistar
local.scopus.subjectSimplexvirus
local.scopus.updated2024-12-01
local.scopus.urlhttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85111614766&origin=inward
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