Neuromodulation approaches for the treatment of major depression: Challenges and recommendations from a working group meeting Estratégias de neuromodulação para o tratamento da depressão maior: Desafios e recomendações de uma força-tarefa

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dc.contributor.authorBrunoni A.R.
dc.contributor.authorTeng C.T.
dc.contributor.authorCorrea C.
dc.contributor.authorImamura M.
dc.contributor.authorBrasil-Neto J.P.
dc.contributor.authorBoechat R.
dc.contributor.authorRosa M.
dc.contributor.authorCaramelli P.
dc.contributor.authorCohen R.
dc.contributor.authordel Porto J.A.
dc.contributor.authorBoggio P.S.
dc.contributor.authorFregni F.
dc.date.accessioned2024-03-13T01:33:00Z
dc.date.available2024-03-13T01:33:00Z
dc.date.issued2010
dc.description.abstractThe use of neuromodulation as a treatment for major depressive disorder (MDD) has recently attracted renewed interest due to development of other non-pharmacological therapies besides electroconvulsive therapy (ECT) such as transcranial magnetic stimulation (TMS), transcranial direct current stimulation (tDCS), deep brain stimulation (DBS), and vagus nerve stimulation (VNS). Method: We convened a working group of researchers to discuss the updates and key challenges of neuromodulation use for the treatment of MDD. Results: The state-of-art of neuromodulation techniques was reviewed and discussed in four sections: [1] epidemiology and pathophysiology of MDD; [2] a comprehensive overview of the neuromodulation techniques; [3] using neuromodulation techniques in MDD associated with non-psychiatric conditions; [4] the main challenges of neuromodulation research and alternatives to overcome them. Discussion: ECT is the first-line treatment for severe depression. TMS and tDCS are strategies with a relative benign profile of side effects; however, while TMS effects are comparable to antidepressant drugs for treating MDD; further research is needed to establish the role of tDCS. DBS and VNS are invasive strategies with a possible role in treatment-resistant depression. In summary, MDD is a chronic and incapacitating condition with a high prevalence; therefore clinicians should consider all the treatment options including invasive and non-invasive neuromodulation approaches.
dc.description.firstpage433
dc.description.issuenumber3
dc.description.lastpage451
dc.description.volume68
dc.identifier.doi10.1590/s0004-282x2010000300021
dc.identifier.issn1678-4227
dc.identifier.urihttps://dspace.mackenzie.br/handle/10899/37266
dc.relation.ispartofArquivos de Neuro-Psiquiatria
dc.rightsAcesso Aberto
dc.subject.otherlanguageClinical guidelines
dc.subject.otherlanguageComprehensive review
dc.subject.otherlanguageECT
dc.subject.otherlanguageMajor depressive disorder
dc.subject.otherlanguageTMS
dc.titleNeuromodulation approaches for the treatment of major depression: Challenges and recommendations from a working group meeting Estratégias de neuromodulação para o tratamento da depressão maior: Desafios e recomendações de uma força-tarefa
dc.typeArtigo de revisão
local.scopus.citations73
local.scopus.eid2-s2.0-77954594804
local.scopus.updated2024-05-01
local.scopus.urlhttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=77954594804&origin=inward
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