Electrocardiographic changes in spondyloarthritis and use of anti-TNF-α drugs: a retrospective study with 100 patients

Página do item simplificado
dc.contributor.authorLongo B.
dc.contributor.authorKirchner L.A.
dc.contributor.authorSimioni J.
dc.contributor.authorCampos A.P.B.
dc.contributor.authorSkare T.L.
dc.date.accessioned2024-03-12T23:53:34Z
dc.date.available2024-03-12T23:53:34Z
dc.date.issued2019
dc.description.abstractOBJECTIVE: To investigate the prevalence of electrocardiographic changes in patients with spondyloarthritis and to correlate these changes with use of anti-tumor necrosis factor-alpha (TNF-α) drugs and HLA-B27 positivity. METHODS: Retrospective study including 100 patients diagnosed with spondyloarthritis according to Assessment of SpondyloArthritis International Society (ASAS) criteria and 50 controls. Epidemiological and clinical features, results of inflammatory activity tests, HLA-B27 positivity, and medication use data were extracted from medical records. Disease activity was assessed using the Bath Ankylosing Spondylitis Disease Activity Index (BASDAI). All participants were submitted to electrocardiogram performed using a 12-lead device; rhythm, heart rate, conduction disorders and QT interval corrected using the Bazett formula were analyzed. RESULTS: Of 100 patients with spondyloarthritis, 51 were on anti-TNF-α drugs and 49 were not. HLA-B27 was detected in 53.1% of patients in the sample. Patients with spondyloarthritis had lower heart rate (p=0.06), longer QT interval (p<0.0001) and higher prevalence of right bundle branch block (p=0.014) compared to controls. Duration of disease was weakly correlated with heart rate (Rho=0.26; 95%CI: 0.06-0.44; p=0.008). The prevalence of right bundle branch block was positively correlated with HLA-B27 positivity. Use of Anti-TNF-α drugs did not interfere with electrocardiographic parameters. CONCLUSION: Patients with spondyloarthritis had lower heart rate, longer QT interval and a higher prevalence of right bundle branch block compared to controls. HLA-B27 positivity was associated with the prevalence of right bundle branch block. Anti-TNF-α drugs had no impact on electrocardiographic findings.
dc.description.firstpageeAO4539
dc.description.issuenumber2
dc.description.volume17
dc.identifier.doi10.31744/einstein_journal/2019AO4539
dc.identifier.issn2317-6385
dc.identifier.urihttps://dspace.mackenzie.br/handle/10899/35290
dc.relation.ispartofEinstein (Sao Paulo, Brazil)
dc.rightsAcesso Aberto
dc.titleElectrocardiographic changes in spondyloarthritis and use of anti-TNF-α drugs: a retrospective study with 100 patients
dc.typeArtigo
local.scopus.citations4
local.scopus.eid2-s2.0-85064207953
local.scopus.subjectAdolescent
local.scopus.subjectAdult
local.scopus.subjectAged
local.scopus.subjectBrazil
local.scopus.subjectBundle-Branch Block
local.scopus.subjectCase-Control Studies
local.scopus.subjectElectrocardiography
local.scopus.subjectFemale
local.scopus.subjectHeart Rate
local.scopus.subjectHLA-B27 Antigen
local.scopus.subjectHumans
local.scopus.subjectMale
local.scopus.subjectMiddle Aged
local.scopus.subjectPrevalence
local.scopus.subjectReference Values
local.scopus.subjectRetrospective Studies
local.scopus.subjectSpondylarthritis
local.scopus.subjectStatistics, Nonparametric
local.scopus.subjectTime Factors
local.scopus.subjectTumor Necrosis Factor-alpha
local.scopus.subjectYoung Adult
local.scopus.updated2024-05-01
local.scopus.urlhttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85064207953&origin=inward
Arquivos
Coleções
Artigos de periódico