Correlation of IL-6 and IL-10 production following bone marrow transplantation with donor cytokine gene polymorphisms

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dc.contributor.authorVisentainer J.E.L.
dc.contributor.authorLieber S.R.
dc.contributor.authorPersoli L.B.L.
dc.contributor.authorMarques S.B.D.
dc.contributor.authorVigorito A.C.
dc.contributor.authorAranha F.J.P.
dc.contributor.authorEid K.A.B.
dc.contributor.authorOliveira G.B.
dc.contributor.authorMiranda E.C.M.
dc.contributor.authorDe Souza C.A.
dc.date.accessioned2024-03-13T01:38:15Z
dc.date.available2024-03-13T01:38:15Z
dc.date.issued2008
dc.description.abstractSeveral candidate gene studies have demonstrated that genetic polymorphisms in cytokine genes contribute to variations in the levels of cytokines produced and this variation may influence the occurrence and severity of complications after stem cell transplantation (HSCT). In this work we compared the serum concentrations of TNF-α, IFN-γ, IL-6, IL-10, and TGF-β1 in 13 recipients following HSCT with the TNF-308, IFNG+874, IL6-174, IL10-1082,-819,-592, and TGFB1 +869,+915 polymorphisms. Serum cytokine levels were assessed using commercial ELISA kits for TNF-α, IFN-γ, IL-6, IL-10, and TGF-β1 (BioSource®, Nivelles, Belgium, Europe). Donor/recipient genotypes for these cytokine polymorphisms were analyzed by polymerase chain reaction-sequence-specific primer (PCR-SSP) with the Cytokine Genotyping Primers Kit (One Lambda, Canoga Park, CA, USA). We found correlation between the levels of IL-6 and IL-10 concentrations following HSCT and the IL6-174 and IL10-1082,-819,-592 polymorphisms, but not for other cytokines investigated in this study. Those with genotypes associated with low production of IL-6 and IL-10 produced lower levels of these cytokines than those with genotypes associated with high or intermediate production of these cytokines (P < 0.05).
dc.description.firstpage475
dc.description.issuenumber6
dc.description.lastpage479
dc.description.volume30
dc.identifier.doi10.1590/S1516-84842008000600011
dc.identifier.issn1516-8484
dc.identifier.urihttps://dspace.mackenzie.br/handle/10899/37559
dc.relation.ispartofRevista Brasileira de Hematologia e Hemoterapia
dc.rightsAcesso Aberto
dc.subject.otherlanguageCytokine
dc.subject.otherlanguageGVHD
dc.subject.otherlanguageHaematopoietic stem cell transplantation
dc.subject.otherlanguagePolymorphism
dc.titleCorrelation of IL-6 and IL-10 production following bone marrow transplantation with donor cytokine gene polymorphisms
dc.typeArtigo
local.scopus.citations1
local.scopus.eid2-s2.0-59749100337
local.scopus.updated2024-05-01
local.scopus.urlhttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=59749100337&origin=inward
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